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BrainTumors/Seizures
| Question | Answer |
|---|---|
| This is a seizure that starts in one area of the brain. The person remains alert + able to interact. Lasts < 2 min | Focal (Onset) Aware Seizure |
| This seizure starts in one area or side of the brain. A person is not aware of their surrounding during it. Typically lasts 1-2 minutes. | Focal (Onset) Impaired Awareness Seizure |
| This type of seizure is usually characterized by an “aura” beforehand. | Focal Impaired Awareness |
| This type of seizure includes automatisms (lip smacking, picking at clothes, fumbling) | Focal Impaired Awareness |
| During this type of seizure, a person loses consciousness, muscles stiffen and jerking movements are seen. | Tonic- clonic |
| This type of seizure usually lasts 1-3 minutes. | Tonic clonic |
| A tonic clonic seizure lasting ____ minutes is a medical emergency. | 5 minutes |
| This type of seizure causes lapses in awareness, sometimes with staring. They begin and end abruptly, lasting only a few seconds. | Absence Seizure |
| These seizures are more common in children. | Absence seizures |
| During this type of a seizure, a person suddenly loses muscle tone so their head or body may go limp. | Atonic seizures |
| These seizures are known as “drop attacks” | Atonic seizures |
| What’s the difference between a focal onset and a generalized onset seizure? | Focal: start in one area or group of cells in one side of the brain Generalized: affects both sides of the brain |
| What are some other medical causes of seizure (other than epilepsy)? | Acute illness/ fever, vascular, trauma, toxic/ metabolic |
| This is a growth of abnormal cells that have formed in the brain. | Brain tumor |
| True or false. Benign brain tumors are not cancer but they still can cause symptoms and require treatment. | True. It is still a serious medical condition. For that reason, they are more often called “non malignant” to clarify that they are made of non-cancerous cells |
| True or false. 1/2 of brain tumors are malignant. | False. <1/3 |
| True or false. Malignant brain tumors generally grow faster and more aggressively than non- malignant | True |
| Based on the WHO Tumor Grades, this grade tumor is the least malignant. Associated with long-term survival. Grow slowly, almost normal appearance on microscope | Grade I |
| Based on the WHO Tumor Grades, this grade tumor is slow growing but can look slightly abnormal under the microscope. Some can spread, sometimes as a higher grade. | Grade II |
| Based on the WHO Tumor Grades, this grade tumor is malignant, actively reproducing abnormal cells which grow into nearby brain tissue. Tend to reoccur. | Grade III |
| Based on the WHO Tumor Grades, this grade tumor is the most malignant, reproduce rapidly and have a bizarre appearance under the microscope. These tumors form new blood vessels. | Grade IV |
| What is the median age at diagnosis for all primary brain tumors? | 60 y/o |
| What is an environmental risk factor for developing a brain tumor? | -Ionizing radiation (X-rays) |
| Are brain tumors usually genetic? | No- only ~5-10% of brain tumors are hereditary |
| These brain tumors arise from the supportive tissues in the brain and SC | Gliomas |
| This type of brain tumor is from the dura or arachnoid mater. | Meningioma |
| What are the 4 types of GLIOMAS? | 1. Astrocytoma 2. Oligodendroglioma 3. Ependymoma/ Ependymoblastoma 4. Medulloblastoma |
| This is the most common type of brain tumor in 30-50 year olds. | Astrocytoma |
| This type of tumor is highly malignant. It is the most common tumor (21% of all adults) | Gliobastoma Multiforme |
| What is the prognosis for a GBM? | 12-14 months (<20% after 1 yr and ~2% after 5 yrs) |
| This type of tumor involves the oligodendrocytes, is slow growing and progresses over years. Most common in 40-60 y/o. | Oligodendroglioma |
| What is the prognosis for an oligodendroglioma? | 9 years |
| True or false. GBMs and oligodendrogliomas affect more women than men. | False! men > women (2:1) |
| What is the tell tale sign for an oligodendroglioma? | Seizures |
| This tumor accounts for 2% of all primary tumors. It arises from cells in the lining of the ventricles. Posterior fossa of SC with sx that can resemble SCI. | Ependymoma/ Ependymoblastoma |
| This is a fast growing tumor that arises from the cerebellum. | Medulloblastoma |
| This tumor is most common in children <10 years old. (18% of all pediatric tumors) | Medulloblastoma |
| What is the prognosis for a medulloblastoma? | Children: 70-80% have 5 yr survival Adults: 55-60% have 5 yr survival |
| This tumor can be benign or malignant, incidence increases with age, and many pts are asymptomatic so usually found incidentally. | Meningioma |
| These two tumors are more common in females. | - Meningioma: females > males (2:1) - pituitary adenoma: females > males (2.25%) |
| When this tumor approaches the optic chiasm , pts may lost their vision. | Pituitary adenoma |
| This type of tumor affects cranial or spinal nerves. There is usually good prognosis but functional impairments may remain. | Schwannoma |
| What nerve is a Schwannoma most likely to occur? | CN VIII (acoustic neuroma) |
| What is a metastatic brain tumor? | A tumor that occurs in the brain due to cancer cells that spread from another part of the body. (Breast, lung, melanoma, colorectal, genitourinary) |
| Where do metastatic brain tumors mostly occur? | Frontal lobe |
| What is the prognosis for a metastatic brain tumor? | 1 month without treatment 6 months with treatment (radiation, steroids) Surgical resection can extend to 16 months |