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MSK 2
Musculoskeletal 2
| Generic Name | Brand Name | Pharmacologic Category | Common Indications | Essential Knowledge |
|---|---|---|---|---|
| methocarbamol (PO) | Robaxin | Skeletal muscle relaxant | Muscle spasm | drowsiness |
| metaxalone (PO) | Skelaxin, Metaxall | Skeletal muscle relaxant | Muscle spasm | drowsiness |
| orphenadrine (PO) | Norflex | Skeletal muscle relaxant | Muscle spasm | drowsiness, dizziness, xerostomia, fatigue, use caution in patients with cardiac disease |
| bupivacaine (IV) | Marcaine, Sensorcaine | Local anesthetic | Epidural anesthesia | hypotension US BOXED WARNING: bupivacaine 0.75% should not be used for OB anesthesia due to reports of cardiac arrest and death, high alert medication |
| lidocaine (transdermal, IV) | Transderm: Lidoderm IV: Xylocaine | Transderm: topical analgesic IV: antiarrhythmic | Transderm: pain IV: ventricular arrhythmias | transderm: dermatits, erythema, urticaria, skin depigmentation, skin edema, patch may remain for up to 12 hours, patch may be cut IV: bradycardia, high alert med |
| allopurinol | Zyloprim | Xathine oxidase inhibitor | gout | diarrhea, nausea, rash, leukopenia, thrombocytopenia, rarely severe hypersensitivity syndrome, esp. in certain Asian populations |
| succinylcholine (IV) | Anectine | Depolarizing NMBA | Neuromuscular blockade for intubation or procedures | hyperkalemia, myalgia, malignant hyperthermia (rare) US BOXED WARNING: acute rhabdomyolysis and hyperkalemia leading to cardiac arrest and death in pediatrics with undiagnosed skeletal muscle disease, high alert med. |
| cyclobenzaprine (PO) | Flexeril | Skeletal muscle relaxant | Muscle spasm | drowsiness, dizziness, xerostomia, fatigue, may cause prolonged cardiac, arrhythmias, and tachycardia, CI within 14 days of MAOI inhibitor intake |
| baclofen (PO) | Lioresal | Skeletal muscle relaxant | Spasticity | drowsiness |
| carisoprodol (PO) | Soma | Skeletal muscle relaxant | Muscle spasm | drowsiness, drug abuse potential |