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Cyclic Peptides

iRAT #4

DrugMOAAntibacterial Activity
Daptomycin Inserts into the bacterial cell membrane and causes membrane depolarization. Gram positive, VRE, VRSA
Fosfomycin Inhibits the addition of phophoenolpyruvate to UDP-NAG and prevents the formation of UDP-NAM Gram positive and gram negative
Bacitracin Inhibits dephosphorylation of bactoprenol pyrophosphate Gram positive
Cycloserine Inhibits alanine racemase that converts l-alanine to d-alanine and D-Ala-D-Ala ligase that synthesizes the D-Ala-D-Ala dipeptide Gram positive and gram negative; used exclusively for tx of tuberculosis (second line agent)
Vancomycin Binds to D-Ala-D-Ala terminus of the NAM-NAG pentapeptide and thereby inhibits transglycosylase activity, preventing further elongation of peptidoglycan and crosslinking. Gram positive Drug of choice for MRSA; C. diff (oral)
Created by: Bmcgraw
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