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Substance Abuse

disulfiram Route PO or subdermal implant
disulfiram Action Inhibits enzyme aldehyde dehydrogenase to block oxidation of alcohol Allows acetaldehyde to accumulate in blood to concentrations that are 5-10x higher than normally achieved during alcohol metabolism unpleasant reaction when consumed with alcohol
disulfiram Use Chronic alcoholism to maintain a state of sobriety
disulfiram Adverse effects most common are headache and metallic/garlic taste in the mouth- decreased libido, rash
disulfiram Contraindications Hypersensitivity Use with alcohol, metronidazole, or paraldehyde Multiple drug dependence Never administered to pts with myocardial disease, coronary occlusion, or psychosis
disulfiram BBW BBW– drug should not be given to pt who has consumed alcohol in past 12 hrs or without their full knowledge
disulfiram RN considerations administered at bedtime,Have periodic liver function tests, Never consume alcohol in any form (mouth wash, hand Sani) Wear medical alert bracelet If consume alcohol- assess cvs , shock, hypokalemia
Created by: amandalw98



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