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phenelzine -MAOI


phenelzine Route PO well absorbed & widely distributed - mood elevation may take 2-8 weeks - metabolized in liver and excreted by kidneys
phenelzine Action Binds irreversibly to MAO increasing concentrations of epinephrine, norepinephrine, serotonin and dopamine in CNS
phenelzine Use Depression when other antidepressants have been unsuccessful in symptom management - rarely used now d/t specific artery dietary regimen required to prevent toxicity
phenelzine Adverse effects hypertensive crisis - can be precipitated by foods containing tyramine, dysrhythmias, drowsiness, dizziness, sexual dysfunction, orthostatic hypotension
phenelzine contraindications pheochromocytoma (tumor of adrenal gland), renal/hepatic impairment,should not have surgery requiring general anesthesia or spinal vasoconstrictors, pts who take other MAOI/weight reduction/ OTC cold or hay fever preparations containing vasoconstrictors
phenelzine RN Considerations take 3x/day PO - a reminder system may be helpful - med may be crushed and mixed w/ fluids or food for pts w/ difficulty swallowing.If patient eats any foods containing tyramine, hypertensive crisis may occur ■ Treatment = phentolamine
tyramine containing foods aged cheese, red wine, beer, fruits, chocolate, fruits, yogurt, sour cream, soy sauce
What does tyramine do? Normally large amounts of tyramine don’t reach systemic circulation, when deactivation is blocked by MAOI, tyramine is absorbed systemically which cause causes sudden release of large amounts of norepinephrine
Created by: amandalw98



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