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N111

Antineoplastic Drugs

QuestionAnswer
Chemotherapy usually targets what part of a cancer cell? Why? RNA and DNA. To prevent mitosis or to induce apoptosis in a cancer cell.
CCNS drugs include... 1. alkylating agents 2. anti-tumor antibiotics 3. hormones
CCS drugs include... 1. antimetabolites 2. mitotic inhibitors
How do alkylating agents work? Prevents cell division by: - Cross-linking of DNA strands - Abnormal base pairings or DNA strand breaks.
What are alkylating agents most effective in doing? Effective against acute and chronic leukemia, lymphomas, solid tumors in breast, ovary, bladder, etc.
Name some alkylating agent drugs. Cyclophosphramide (Cytoxan) Nitrosoureas.
What is nitrosoureas most effective is doing? Useful in the treatment of brain cancer.
Created by: aznizzy2
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