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Parkinson / Ner Sys
ch 17, therapeutic agents for the nervous system - pharm tech
Question | Answer |
---|---|
Parkinson disease | progressive disorder associated with the loss or deficiency of dopamine, a neurotransmitter |
TRAP symptoms | tremor, rigidity, akinesia (for bradykinesia), and postural instability |
Sinemet | levodopa / carbidopa *levodopa / carbidopa class |
Mirapex | pramipexole *dopamine agonist |
Requip | ropinirole *dopamine agonist |
Neupro | rotigotine *dopamine agonist |
Cogentin | benztropine *anticholinergic |
Artane | trihexyphenidyl *anticholinergic |
Symmetrel | amantadine *anticholinergic |
Catechol-O-Methyltransferase inhibitors | COMT inhibitors; prevent the peripheral conversion of levodopa by the enzyme COMT |
Comtan | entacapone *COMT inhibitor |
Tasmar | tolcapone *COMT inhibitor |
Monoamine Oxidase-B Inhibitors | MAO-B Inhibitors; inhibition of MAO-B decreases the metabolism of dopamine in the CNS |
Azilect | rasagiline *MAO-B Inhibitors |
Eldepryl or Zelapar | selegiline *MAO-B Inhibitors |
5 classes of PD medications | levodopa/carbidopa, dopamine agonists, anticholinergics, COMT inhibitors, and MAO-B inhibitors |