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Chapter 6

Tryptophan Hydroxylase converts tryptophan to 5-hydroxytryptophan (5-HTP)
Aromatic amino acid decarboxylase (AADC) converts 5-HTP to 5-HT (serotonin)
TPH2 expressed by serotonergic neurons
TPH1 expressed by 5-HT- secreting cells in the gut and melatonin-secreting cells in the pineal gland
Serotonin Synthesis can be stimulated by giving an animal a large dose of tryptophan or 5-HTP
Insulin stimulates uptake of amino acids, except tryptophan
Para-chlorophenylalanine (PCPA) blocks 5-HT synthesis by irreversibly inhibiting tryptophan hydroxylase
Para-chlorophenylalanine (PCPA) used to help determine role of 5-HTP in behavioral functions
Vesicular monoamine transporter (VMAT2) transports Serotonin in vesicles
Reserpine (VMAT blocker) depletes 5-HT, which is broken down when not protected in vesicles
Terminal autoreceptors inhibits 5-HT release
Somatodendritic autoreceptors indirectly inhibit release by slowing the rate of neuron firing
Para-chloroamphetamine mainly used experimentally
Fenfluramine prescribed for appetite suppression in obese patients
3,4- methylenedioxymethamphetamine (MDMA) a recreational drug
Ecstasy Also known as MDMA
5-HT transporter or SERT removes 5-HT by the synaptic cleft via reuptake
Serotonin reuptake inhibitors (SSRIs) blocks transporters. Example "Fluoxetine" (Prozac)
5-hydroxyindoleacetic acid (5-HIAA) breakdown of 5-HT
WAY 100635 5-HT1A receptor antagonist
5-HT2A receptors large number in the cortex
5-Ht 2a agonist 1-(2/5-dimethoxy-4-iodophenyl)-2aminopropane (DOI)
5-HT2a antagonists Ketanserion & ritanser
Hallucinogenic (hallucination-producing) DOI & related drugs in humans
Lysergic acid diethylamide (LSD) stimulate 5-HT2A receptors
Clozapine (clozaril) & Risperiodne (Risperdal) blocks 5-HT2A receptors and D2 dopamine receptors. used to treat schizophrenia with fewer side effects
Sumatriptan (Imitrex) & Zolmitriptan (Zomig) 5-HT 1B/1D that causes constriction of the vessels, which eases pain
Ondanserton (Zogran), granisetron (kytril) & palonoserton (Aloxi) 5-HT3 antagonists that are used to treat nausea
Serotonin deficiency hypothesis proposes that low CNS serotonergix activity is associalted with hyperaggressiveness
Created by: Ciera9105



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