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Pharm: Ch 2

absortion process occurs at the time a drug enter the body to time it enters the bloodstream to circulate
agonist drug that produces effects similar to those produced by naturally occurring hormones, neurotransmitters, and other subs
antagonist drug that inhibits cell function by occupying receptor sites
antidote subs that relives, prevents or counteracts effect of poison
bioavailability portion of a drug dose that reaches the systemic circulation and is available to act on body cells
biotransformation when drugs are altered from their original form into a new form by the body metabolism
distribution transport of drug molecules within the body; drug injected or absorbed into bloodstream, carried by blood and tissue fluids to sites of action, metabolism, and excretion
enterohepatic recirculation drugs or metabolites that are excreted in bile, reabsorbed from small intestines, returned to liver, metabolized, and excreted in urine
enzyme induction production of larger amts of drug-metabolizing enzymes by liver cells, process accelerates drug metabolism because larger amts of the enzymes (and binding sites) allow larger amts of a drug to metabolized during a given time
enzyme inhibition molecule binds to enzymes and inhibits activity
excretion elimination of a drug from the body, effective excretion requires adequate functioning of the circulatory sys and of the organs of excretion (kidneys, bowel, lungs, and skin)
first-pass effect initial metaolism of some oral drugs as they are carried from the intestine to the liver by the portal circulatory sys prior to reaching the systemic circulation for distribution to site of action
hypersensitivity immune-mediated reation to a drug
Created by: EmilyGiardina



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