Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Drug Action Exam 3
Drug Action- Toxic substances
| Question | Answer |
|---|---|
| Toxidrome | Classic constellation of symptoms related to a toxin |
| Anticholinergic Toxidrome | Red as a beet, Hot as a hare, Mad as a hatter, Blind as a Bat, Dry as a bone, seizing like a squirrel |
| Naloxone | Used in Heroin abusers,over sedation, unknown coma patients |
| Flumazenil MOA | Mild to excessive benzodiazine sedation |
| Flumazenil dosing | 0.1mg/min up to 1mg |
| Physostigmine MOA | Carbamate that inhibits acetylcholinesterase |
| Physostigmine Use | Excessive muscaranic effects, Av block, bradycardia, seizures |
| Atropine MOA | Competitive antagonist of ACh at muscaranic receptor and in CNS |
| Atropine Use: | Clear secretions of the trachialbranchiol, Increase breathing (Sarin Gas) |
| Pralidoxime MOA | Nucleophillic oxime regenerates AChE at muscaranic, nicotinic and CNS sites by removing a phosphate group. Great to decrease muscle weakness. |
| Flumazenil DO not Use | Unknown coma, risk of seizure, risk of withdraw, abnormal ECG or vial signs, shorter T1/2 than BZD |
| CroFab USE | Binds the venom, therefore same dose for all 4-6IV vials |
| Ethanol MOA | inhibitor of active metabolite of Methanol or ethylene glycol |
| Fomepizole MOA | Specifice inhibitor of ALDH |
| Cyanide Antidote Kit | Amyl NItrile inhalent +Sodium Nitrile IV + Sodium thiosulfate |
| Amyl Nitrate & Sodium Nitrite Create | Methemoglobin that binds CN strongly Pulls it away from the ETC |
| Methylene Blue USE | Used to treat Metehomogloninemia coverts to hemoglobin |
| Octreotide MOA | Inhibits pancreatic insulin secretion |
| Octreotide Use If | Sulfonylurea ingestion suspected and at least 1 episode of hypoglycemia |
| Nomogram IF | rWithin 4-24 hours +Single ingestion |
| Treat with NAC IF | ALT >50IU/L and/or APAP >10mcg/mL |
| NAC PO Dose | 140 mg/kg bolus then 70mg/kg q 4 x 17 doses (72hrs) |
| NAC IV Dose | 150mg/kg over 15-60 minutes , then 50mg (12.5mg/kg/hr) over 4 hours, then 100mg (6.25mg/kg/hr) over 16 hours |
| NAC Children IV | 3.75 over 15-60minutes, 1.25ml/kg over 4 hours, 2.5ml/kg over 16 hours |
| NAC Effect | 100% effective if given w/in 8 hours of OD |
| NAC hepatic failure | 50% in Mortality, use of pressors, hepatic encephalopathy |
| NAC Alcoholic | Max dose safe |
| NAC-Transplant | Kings college criteria-1 pH <7.3 PT >100 sec (INR>6) and SCR >3.4 AND III or IV encephalophy |
| Liver failure | High lactate |
| ASA Adult toxic dose | 150mg/kg |
| ASA min lethal dose | 450mg/kg |
| ASA MOA | Uncoupleted oxidative phosphorylation + Stimulation of respiratory center+ Inhibit COX+ alter capillary permeability |
| Clinical Effects of ASA OD | Acid/Base (anion gap)+ cerebral /pulmonary edema+ CNS (agigation, seizures) Tinnitis, GI |
| ASA Elimination | Toxic ASA levels >30ml/DL + give 1-2 amps NaHco3 blous and then 3 amps +1 L D5W +20meQ Potassium keep Ph >7.5 |
| HD ASA | >90-100mg/DL |
| Elderly ASA toxicity | >50mg/mL |
| Gi decontimination | Lavage (suction) +Charchol+ Whole bowel irrigation |
| CCB +BB | Decrease:SA HR, Conduction, contractility=hypotension and increased ERP |
| Propranolol | CNS penetration, CNS depression & seizure, bradycardia, dysrhythmia, hypoglycemia |
| CCB MOA | Block calcium channel, vasodialation, chronotropy (SA node), hyperglycemia, Peak in 0.5-6 hours |
| CCB+ BB OD treatment | 500 ML fluides, Atropine (bradycardia s/s) Dopamine, Calcium(1-2 amps), glucagon(2-5 amps) |
| Digoxin acute OD | Digibind 10-20vials |
| Digocin chronic OD | Digibind 2-5 vials |
| Digoxin | Watch hypokalemia and MG |
| Digocin MOA | vagal stimulation and sinus bradycardia/arrest, PR prongulation, nodal block |
| Digoxin:Acute toxicity | N/V, Super ventricular tachycardia, with heart blcok or bradydydsrhythmias, hyperkalemia, DIg level markedly elevated |
Created by:
liza001
Popular Pharmacology sets