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Seizures 411

Seizures

QuestionAnswer
Short alterations in consciousness, confusion, repetitive unusual movements, behavioural changes Partial seizures
Loss of consciousness, generalized motor activity possible, both hemispheres of brain involved from beginning Generalized seizures
Motor, sensory, autonomic, or psychic signs, no loss of consciousness Simple partial seizures
Impaired consciousness, not necessarily loss of consciousness Complex partial seizures
Absence, tonic-clonic, tonic, atonic, myoclonic Primarily generalized seizures
Phenytoin for parital and gen tonic-clonic, No absence
Carbamazepine for DOC for complex partial
Phenobarbital for DOC for infantile spasms and neonatal seizures, no absence
Valproic acid for DOC for generalized and most partial/neonatal
Ethosuximide for Absence
Clonazepam for Myoclonic and atonic
Gabapentin for Partial and neuropathic pain
Primidone is metabolized to: Phenobarbital
Fosphenytoin metabolized to: Phenytoin
Should be separated from tube feedings: Phenytoin and Carbamazepine
Autoinducer Carbamazepine
Monitor for toxicity Phenytoin, Carbamazepine, Valproic acid
Lamotrigine major ADR Rash (stevens-johnson rxn)
Topiramate major ADR Cognitive impairment
Used in treatment of seizures and status epilepticus BZDs
Gabapentin interaction Antacids can reduce availability by 20%
CNS depression, gingival hyperplasia, hirsutism, acne Phenytoin ADRs
Nausea, blurred vision, HA, rash, bone marrow suppression Carbamazepine ADRs
Decreases warfarin and OCP Carbamazepine interactions
CNS depression and dependence Phenobarbital ADRs
Decreases efficacy of OCP Phenobarbital & Carbamazepine
Nausea, vomiting, diarrhea, drowsiness, weight gain Valproic Acid ADRs
Nausea, vomiting, lethargy, pruritis, urticaria Ethosuximide ADRs
Drowsiness, dizziness, resp depression, dependence Clonazepam ADRs (benzodiazepine)
Ataxia, impaired concentration, thinking abnormally, weight loss Topiramate ADRs
Created by: lbreimeir
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