Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Urinary Drugs 411
Urinary
| Question | Answer |
|---|---|
| 60-70% salt/water reabsorbed | Proximal tubule |
| Very low Na permeability | Descending loop of Henle |
| High Na permeability, 20-25% Na reabsorbed | Ascending loop of Henle |
| 5-10% Na reabsorbed, depends on aldosterone | Distal Convoluted Tubule |
| Water reabsorbed if ADH present | Collecting Duct |
| Prevents reabsorption of bicarbonate. Increases osmotic pressure. Cause osmotic diuresis. | Acetazolamide |
| Used primarily to produce alkaline urine | Acetazolamide |
| Diuretic effects loss with chronic use | Acetazolamide |
| Not as effective as diuretics that prevent Na reabsorption | Acetazolamide |
| Inhibit Na reabsorption at distal convoluted tubule | Thiazide Diuretics |
| Moderate potency, can only affect 10% of Na load | Thiazides |
| Used short term for mild edema | Thiazides |
| Loses diuretic effect after about 1-2 weeks, antihypertensive effect remains chronically | Thiazides |
| Thiazide Diuretics Drugs | Chlorothiazide, HCTZ, Metolazone, Indapamide |
| Arrhythmias, orthostatic hypotension, muscle weakness/cramps/pain | Consequences of Thiazide-induced hypokalemia |
| Thiazides ADRs | hypokalemia, hyperuricemia, hyperglycemia, hypercholesterolemia |
| Most effective agents, infinite dose response | Loop Diuretics |
| For moderate to severe edema | Loop Diuretics |
| Disease states where thiazides must be used w/ caution | severe renal impairment, DM, electrolyte imbalances, pregnant, elderly, gout |
| Loop Diuretics Drugs | Bumetanide, Ethacrynic acid, Furosemide |
| Loop Diuretics ADRs | Hypokalemia, hypomagnesemia, hyperuricemia, hypercholesterolemia, hypovolemia, ototoxicity |
| Consequences of Thiazide-induced hypokalemia | Arrhythmias, orthostatic hypotension, muscle weakness/cramps/pain |
| hypokalemia, hyperuricemia, hyperglycemia, hypercholesterolemia | Thiazides ADRs |
| Hypokalemia, hypomagnesemia, hyperuricemia, hypercholesterolemia, hypovolemia, ototoxicity | Loop Diuretics ADRs |
| K+ sparing diuretics drugs | Amiloride, Spironolactone, Triamterene |
| Mild diuretics, usually used w/ other diuretics | K+ sparing diuretics |
| K+ induced hyperkalemia risk groups | renal impairment, DM, elderly |
| Signs and symptoms of hyperkalemia | Parasthesias, muscular weakness flaccid paralysis of extremeties, bradycardia, shock, ECG abnormalities |
| Parasthesias, muscular weakness flaccid paralysis of extremeties, bradycardia, shock, ECG abnormalities | Signs and symptoms of hyperkalemia |
| Consequences of Thiazide-induced hypokalemia | Arrhythmias, orthostatic hypotension, muscle weakness/cramps/pain |
| Antagonizes the effects of aldosterone, diuretic activity only in presence of aldosterone | Spironolactone |
| Used in combo w/ HCTZ to prevent HCTZ induced hypokalemia | Spironolactone |
| Causes hirsutism, endocrine problems | Spironolactone |
| Increase intravascular osmotic pressure. Keep water and Na in tubule | Osmotic Diuretics |
| Acetazolamide | Proximal tubule diuretic |
| Chlorothiazide | Thiazide Diuretic (distal conv. tubule) |
| Hydrochlorothiazide (HCTZ) | Thiazide Diuretic (distal conv. tubule) |
| Indapamide | Thiazide Diuretic (distal conv. tubule) |
| Amiloride | K+ sparing diuretic |
| Spironolactone | K+ sparing diuretic |
| Triamterene | K+ sparing diuretic |
| Bumetanide | Loop Diuretic |
| Ethacrynic acid | Loop Diuretic |
| Furosemide | Loop Diuretic |
| Mannitol-IV | Osmotic Diuretic |
| Urea-IV | Osmotic Diuretic |
| Glycerin-PO | Osmotic Diuretic |
Created by:
lbreimeir
Popular Pharmacology sets