Save
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Oncology II

Specific Cell Cycle Cytotoxic Drugs: Pyrimidine Analog Antimetabolites

TermDefinition
What is the MOA of pyrimidine analog antimetabolites? - inhibits the synthesis of pyrimidine
which phase of the cell cycle does pyrimidine analog antimetabolites acts on? - phase S
How dose the pyrimidine analog antimetabolites inhibits the pyrimidine synthesis during S-phase? - TWO active metabolites: 1- F-UMP: incorporate RNA --> replace U ( uracil) --> no cell growth ( fuckup the RNA) 2- 5-DUMP: inhibits thymidylate synthetase ( dump the thymidylate in the trash)
What are the common pyrimidine analog antimetabolites? 1- Fluorouracil ( adrucil) 2- CApecitabine ( prodrug 5-FU) 3- Cytarabine conventional 4- cytarabine liposomal 5- Gemcitabine
fluorouracil ( adrucil) vs. fluorouracil ( efudex) vs. Fluorouracil ( carac, tolak and fluoroplex)? - fluorouracil ( adrucil): conventional - fluorouracil ( efudex): basal cell carcinoma - CREAM - fluorouracil ( carac, tolak, and fluoroplex) -- for actinic keratosis - GEL
What is the role of leucovorin when given with fluorouracil? - enhance the efficacy of 5-FU via 5-FU binds tightly to the target enzyme ( thymidylate synthetase)
Which medication enhance the binding affinity of 5-FU to the targeted enzymes ( thmidylate synthetase) ? - Leucovorin
What is a RIKS factor that increases the potential of 5-FU and capecitabine toxicity? DPD deficiency ( Di-hydropyrimidine dehydrogenase)
When is the use of Capecitabine tablet is C/I ? - renal impairment CrCL < 30
what are some major clinical factors Capecitabine been associated with? (BBW) - increases the INR during the tx + 1 month after d/c treatment (BBW)
What are some common monitoring parameters for Capecitabine? whats the rational? SCr: C/I < 30 ml/min INR: increases the pt INR
What is the drug of choice to manage 5-FU or Capecitabine induced toxicity in patient with DPD deficiency? - give uridine triacetate 1- overdose 2- early toxicity
Which pyrimidine analog antimetabolites associated with FLU-LIKE sxs? - cytarabine and gemcitabine
which pyrimidine analog antimetabolites the infusion rate AFFECTS it's efficacy and toxicity? - Gemcitabine - PK affects PD
What is the route of Administration of Cytarabine liposomal? IT: intrathecal administration
which pyrimidine analog antimetabolites associated with chemical arachnoiditis? cytarabine liposomal IT administration
What are some consideration for managing cytarabine liposomal IT induced arachnoiditis? - Give dexamethasone FYI: arachnoiditis : pain disorders 2/2 to inflammation of the arachnoid that protects and surrounds the spinal cord>
describe cytarabine syndrome? Flu like sxs: 1- fever 2- bone pain 3- rash 4- myalgia
which pyrimidine analog antimetabolites associated with cardiotoxicity? - fluorouracil - capecitabine
which pyrimidine analog antimetabolites doesn't induce HAND AND FOOT SYNDROME? ALL EXCEPT Gemcitabine
which pyrimidine analog antimetabolites associated with photosensitivity? - fluorouracil - capecitabine
which pyrimidine analog antimetabolites associated with hepatotoxicity? - All except fluorouracil and capecitabine
which pyrimidine analog antimetabolites associated with pulmonary toxicity? - All except fluorouracil and capecitabine
which pyrimidine analog antimetabolites have BBW for Myelosuppression & hepatotoxicity? Cytarabine and gemciabine
which pyrimidine analog antimetabolites has BBW for pulmonary toxicity ? Gemciabine ( gym and inhaling toxic)
which pyrimidine analog antimetabolites induces conjunctivitis? Cytarabine tx with steroid eye drop
BBW that is specific for gemcitabine vs cytarabine vs. liposomal cytarabine? pulmonary toxicity vs. GI vs. arachnoiditis
which pyrimidine analog antimetabolites we use steroid in conjunction to tx side effects? cytarabine : - conjunctivitis - arachnoiditis
Created by: Smoham38
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards