Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Oncology II

Specific Cell Cycle Cytotoxic Drugs: Topoisomerase I & II Inhibitors

TermDefinition
What is the MOA of topoisomerase I inhibitors? - inhibits the coiling and uncoiling of the dDNA during S-PHASE --> breaks DNA & prevents Regulation
Which PHASE of the cell cycle does the topoisomerase I inhibitors acts? S phase ( remember S #1)
What are some common topoisomerase I inhibitors drugs? - Irinotecan - Topotecan
Which topoisomerase I inhibitors associated with high risk of acute and delayed diarrhea? - Irinotecan 2/2 its acute cholinergic sxs
What is the recommended treatment of irinotecan induced acute diarrhea? Atropin
What is the recommended treatment of irinotecan induced delayed diarrhea? Loperamide
what is the loperamide dose in irinotecan indued delayed diarrhea? and how it's different from normal dosing? up to 24mg/day vs 12mg/day
what are some common irinotecan indued anticholinergic sxs ? - flushing - sweating - abd cramps - diarrhea
What are some of the genetic factors that increases the risk of irinotecan indued delayed diarrhea ? homozygous UGT1A1*28
What are some genetic factor that increases the risk of irinotecan indued neutropenia? homozygous UGT1A1*28
What is the TOP TWO factors ( requirements) prior to initiating topotecan in cancer pt? (BBW) - ANC >1500 cells/mm3 - platelets > 100K cells/mm3
What is the COMMON BBW of USING topoisomerase I and II inhibitors? Myelosuppression ( BBW)
What is the MOA of topoisomerase II inhibitors? inhbitis the coiling and uncoiling of the dDNA during the G2 phase --> breaks DNA and prevents regulation
Which PHASE of the cell cycle dose the topoisomerase II inhibitor acts on? G2 phase ---( isomerase II)
What are the three main formulations of topoisomerase II inhibitors drug? - Etoposide 1- Etoposide IV 2- Etoposide phosphate 3- Etoposide refrigerated capsule
what is unique about etoposide capsule? - needs to be refrigerated - if dose > 200--->divide the dose 2/2 low bioavailability
What is the ratio of conversion between etoposide IV ---> etoposide oral ( Capsule)? - capsule has 50% bioavailability - so the oral dose = 2X IV dose
Which patient population benefit from etoposide phosphate formula and why? - pt with FLUID restriction - conc needed >0.4mg/ml - no need to maintain <0.4mg/ml conc
What are some recommendation if etoposide IV to be used in a patient? - infuse over 30-60 min 2/2 infusion rate related HYPOTENSION
What are some concerns of using etopside IV? Infusion rate related hypotension
What are some consideration while preparing etopside IV? - Conc << 0.4 mg/ml 2/2 poor water soluble - use non PVC IV bag and tuve 2/2 leaching of DEHP
What are the topoisomerase II class side effects? 1- hypersensitivity rxn 2- anaphylaxis 3- 2nd malignancies
what are the topoisomerase I class side effects? - GI: n/v/d/ abd pain - alopecia
Created by: Smoham38
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards