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Oncology II
Specific Cell Cycle Cytotoxic Drugs: Taxanes
| Term | Definition |
|---|---|
| What is the MOA of taxanes? | - inhibits the microtubules during M-phase - similar MOA as vinca alkaloids |
| What is the common side effect of taxanes? | - 2/2 to microtubules inhibition---> axonal transport in neurons --> peripheral sensory neuropathies |
| What is taxanes CLASS BOXED warning? | - SEVERE infusion related hypersensitivity reaction and fatal anaphylaxis 2/2 to the solvent system - managed by premedication |
| What are some IMPORTANT consideration while dosing taxanes? | - HEPATIC impairment - dose adjustment |
| What are some consideration if taxanes is to be given with platinum based therapies such as cisplatin and carboplatin? | - cisplatin and carboplatin REDUCE the elimination of taxanes - SO GIVE taxanes BEFORE platinum based therapies |
| Which taxanes does NOT induce hypersensitivity reaction and fatal anaphylaxis upon administration? | paclitaxel albumin bound ( abraxane) 2/2 no solvent system, however, its paclitaxel bound to albumin |
| which taxanes does NOT require premedication prior to administration? | paclitaxel albumin bound ( no risk of hypersensitivity rxn) |
| Which taxanes require premedication prior to administration? which of them needs 3 days of premedication? | - paclitaxel - docetaxel - cabazitaxel - *** 3 days of premedication: docetaxel |
| what are the recommendation for premedication in PACItaxel and CABAzitaxel induced infusion related hypersensitivity ? | 3 Drugs: - duphenhydramine - corticostreoid - H2RA |
| what makes DOCEtaxel premedication plan different from other PACITaxel and CABAzitaxel? | - 3 days of premedication with Corticosteroids - 1 day prior to docetaxael ( 1 steroid --> docetaxel--> 2 days of steroid) |
| What are the main concerns with using DOCEtaxel without premedication with corticosteroid ( dexamethasone) for 3 days? | - FLUID RETENTION 1- pleural effusion ( fluid build up between lung and chest) 2- cardiac tamponade ( compression of the heart) 3- edema |
| What is a different concern using DOCEtaxel formulation? | - some formulation has alcohol --> sxs of EtOH- intoxication |
| Which taxanes drug causes fluid retention? (BBW) | DOCEtaxel (BBW) |
| What are some common taxanes CLASS BBWs? | - Severe infusion related hypersensitivity rxn - myelosuppresion |
| What are some common side effects of taxanes? | - peripheral sensory neuropathy - pain: myalgias, arthralgias - Hepatotoxicity ( dose adjustment ) *** - alopecia - |
| which taxanes causes less of these side effects? | cabazitaxel |
| what are some IMPORTANT considerations while administrating the taxanes? | -USE NON-PVC bag 2/2 DEHP ( softener of PVC) leaching |
| which taxanes can be administered with PVC bag? | paclitaxel albumin bound |
| what is the recommended solvent system for the following taxanes? 1- paclitaxel 2- docetxael | 1- polyoxyl35/polyoxethylated caster oil ( cremophor EL) 2- polusorbate 80 |
Created by:
Smoham38
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