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Oncology II
Specific Cell Cycle Cytotoxic Drugs: Vinca Alkaloids
| Term | Definition |
|---|---|
| Which cell cycle stage dose vinca alkaloids interfere with? | - M-phase - Mitosis ( cell divides into two daughter cells) |
| What is the MOA of vinca alkaloids? | - inhibits the microtubules during the M phase |
| What are the COMMON SIDE EFFECT ( CLASS SIDE EFFECT) of vinca alkaloids? | - peripheral and autonomic neuropathy |
| what are some examples of vinca alkaloids induced peripheral sensory neuropathy ? | 1- paresthesia |
| what are some examples of vinca alkaloids induced autonomic neuropathy? | - constipation - gastroparesis |
| what is the proposed MOA of vinca alkaloids induced peripheral or autonomic neuropathy? | - vinca alkaloids targets the microtubules and inhibits them - Microtubules are important in axonal transport of neurons |
| which vinca alkaloids is associated with high risk of neurotoxicity ( neuropathy and CNS toxicity)? | vinCRISTINE |
| Which vinca alkaloids is associated with high risk of bone marrow suppression ( myelosuppression? | vinBLASTINE and vinorelBINE |
| What is the ONLY route of administration for vinca alkaloids? | - IV ONLY ( ALLLLL AGENTS) fatal if other roa |
| What is the recommended management of vinca alkaloids induced extravasation? | - vina Alkaloids: POTENT VESICANTS 1- WARM compressor 2- Hyaluronidase ( tx extravasation) |
| which Vina alkaloids are CYP 3A4 substrate? | vinCRISTINE |
| what are some DDI with vinCRISTINE? and what's the proposed MOA? | - proposed MOA: via CYP3A4 - DDI: Azole anti fungal - Result: increases the risk of toxicities ( peripheral neuropathy, seizure and paralytic ileum) |
| Which Vina alkaloids doesn't induce myelosuppression? | - vincristine |
| Which vina alkaloids has the highest risk of inducing myelosuppression? | Vinblastine and vinorelbine |
| what are some common recommendation to prevent/minimize the risk of vincristine induced neurotoxicity ( CNS and neuropathy)? | dose capped at 2 mg/dose |
| What are some recommendation to prevent VINCRISTINE inadvertent administration intrathecally IT ? | - prepare vincristine in small IV bag ( piggy back) - NEVER in Syringe |
| Why is VINCRISTINE administered IV ONLY and NEVER IT? | - IT administration ---> progressive paralysis and death |
| What are some common side effects of Vina alkaloids? | - peripheral sensory neuropathy ( paresthesias) - autonomic neuroapthy - SIADH |
| What is the common BBW of ALLLL vina alkaloids? | vesicants |
| Which other class of cell cycle specific cytotoxic drug target M-phase? | - taxanes BOTH taxanes and Vinca alkaloids target M-phase |
Created by:
Smoham38
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