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Oncology II
Non-Specific Cell Cycle Cytotoxic Drugs: Anthracyclines
| Term | Definition |
|---|---|
| what is the MOA of anthracyclines? | 1- intercalation into the DNA 2- inhibits topoisomerase II 3- creating free oxygen radical --> cell destruction |
| Which common side effect is associated with the use of anthracyclines? | Cardiotoxicity |
| what types of anthracycline induced Cardiotoxicity? | 1- cardiomyopathy ( the heart is enlarged and weak) 2- heart failure ( heart doesn't pump strong enough to meet the body needs) |
| What is the common RISK factor that causes anthracycline induced cardiotoxicity? | the life time cumulative dose |
| Which anthracycline drug has the HIGHEST risk of inducing cardiotoxicity? | doxorubicin |
| Which anthracycline drug has the highest risk of inducing extravasation? | doxorubicin |
| Which chemoprotective drug is used in-conjunction with doxorubicin to prevent cardiotoxicity? | Dexrazoxane ( zinecard) |
| which chemoprotective drug is used in conjucetion with doxorubicin to prevent extravasation? | dexrazoxane ( totect) |
| Which anthracycline drug is NOT vesicants? | liposomal doxorubicin |
| What are the 3 COMMON side effect of anthracycline drugs? (BBW) | - myocardial toxicity - myelosuppression - 2nd malignancy |
| what is a unique BBW associated with the use of liposomal doxorubicin? | infusion related reaction |
| Which anthracycline drug cause infusion- related reaction? | liposomal doxorubicin |
| which anthracycline drug cause hand-foot syndrome ? | liposomal doxorubicin |
| Which anthracycline is not considered vesicant? | liposomal doxorubicin |
| Which anthracycline causes red urine discoloration? | all except mitoxantrone ( blue) |
| What is the max cumulative life dose of doxorubicin? | 450-550 mg/m2/ life time |
| which anthracycline drugs are NOT emetogenic ( low risk CINV)? | - liposomal doxorubicin - mitoxantrone: irritant with vesicant like ( no n/v) |
| what is the CINV classification of anthracycline? | moderate to high emetogenic |
| When is the use of anthracycline except mitoxantrone and liposomal doxorubicin is C/I? | - pre- existing myocardial insufficiency - severe hepatic impairment |
| Which anthracycline associated with HIGH risk of heptotoxtocity? | daunorubicin |
| which anthracycline associated with HIGH risk of renal impairment? | daunorubicin and idarubicin |
| Which anthracycline the dose adjustment in hepatic impairment is NOT needed? | valrubicin |
| List the common anthracycline drugs? | - Rubicin: doxorubicin, daunorubicin, epirubicin, idarubicin, and valrubicin - liposomal rubicin: liposomal-doxorubicin anthracenedione: mitoxantrone |
| which anthracycline is give as bladder instillation ( given directly into the bladder through a urinary catheter)? | valrubicin |
| How dose the pharmacist calculate the life time dose of doxorubicin? | - dose mg/m2/cycle X # cycles = cumulative lifetime dose mg/m2 - max lifetime dose of doxorubicin is 450mg/m2-550mg/m2 |
| what are some prophylactic considerations of using doxorubicin? | - max lifetime dose 450-550mg/m2 - if the cumulative dose > 300 ---> use Dexrazoxane chemo-protectant ( Zinecard) |
| what are some common monitoring parameters if patient to receive doxorubicin? | LVEF before and after |
Created by:
Smoham38
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