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Oncology II

Non-Specific Cell Cycle Cytotoxic Drugs: Platinum-Based Agents

TermDefinition
What is the MOA of Platinum-Based chemotherapy? - cross link with DNA - interfere with DNA synthesis and Cell replication
What is the most common toxicities associated with the use of Platinum based chemotherapy 2/2 to platinum content ? 1- nephrotoxicity 2- ototoxicity 3- peripheral sensory neuropathy
Which platinum based chemotherapy is associated with the highest incidence of nephrotoxicity ? Cisplatin
Which platinum based chemotherapy is associated with the highest incidence of CINV ? Cisplatin
What is some IMPORTANT consideration if platinum based agents is to be used? renal function -- > dose adjustment
List the common platinum based chemotherapy agents? CISplatin CARBOplatin OXALIplatin
Which platinum based chemotherapy agent associated with higher incidence of nephrotoxicity? cisplatin
Which platinum based chemotherapy agent associated with higher incidence of ototoxicity? cisplatin
Which platinum based chemotherapy agent associated with higher incidence of dose-dependent myelosuppression? carboplatin
Which platinum based chemotherapy agent associated with higher incidence of acute sensory neuropathy exacerbate with cold ? oxaliplatin
What are some consideration to minimize the risks of cisplatin induced nephrotoxicity ? - cap cisplatin dose to 100mg/m2 PER CYCLE - hydration prior to each dose with IV 1-2 L - Amifostine: chemoprotectant
What are some common monitoring parameters of cisplatin induced nephrotoxicity? - RENAL FUNCTION: intake = output - Mg & K - Hydration
What are some common monitoring parameters of cisplatin induced ototoxicity? - audiograms 1- baseline 2- each dose
What is the CINV classification of Cisplatin? HIGH emetogenic -----> use 3-4 drugs
What is the dosing method of Carboplatin? Carboplatin doses based on Targeted AUC
What is the dosing formula of carboplatin? - calvert formula total carboplatin dose (mg) = AUC X (GFR +25) - GFR: capped at 125ml/min - AUC: 2-8 mg/ml X min
What is an important counseling point for patient receiving Oxaliplatin? - onset of acute sensory neuropathy - 1-7days after chemo - AVOID COLLLLLD
When is the use of cisplatin C/I? - myelosuppression - renal impairment - hearing impairment
when is the use of Carboplatin C/I? - myelosuppresion
Which platinum based compounds causes myelosuppresion? (BBW) cisplatin carboplatin
which platinum based compounds causes renal toxicity? (BBW) - cisplatin
which platinum based compounds causes ototoxicity? (BBW) - cisplatin
which platinum based compounds after the 6th cycle associated with anaphylactic like reaction ? (BBW) - Carboplatin ( after the 6th cycle)
which platinum based compounds has minimum CINV? oxaliplatin
which platinum based compounds have the highest CINV? cisplatin
Created by: Smoham38
 

 



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