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Oncology II
Non-Specific Cell Cycle Cytotoxic Drugs: Platinum-Based Agents
| Term | Definition |
|---|---|
| What is the MOA of Platinum-Based chemotherapy? | - cross link with DNA - interfere with DNA synthesis and Cell replication |
| What is the most common toxicities associated with the use of Platinum based chemotherapy 2/2 to platinum content ? | 1- nephrotoxicity 2- ototoxicity 3- peripheral sensory neuropathy |
| Which platinum based chemotherapy is associated with the highest incidence of nephrotoxicity ? | Cisplatin |
| Which platinum based chemotherapy is associated with the highest incidence of CINV ? | Cisplatin |
| What is some IMPORTANT consideration if platinum based agents is to be used? | renal function -- > dose adjustment |
| List the common platinum based chemotherapy agents? | CISplatin CARBOplatin OXALIplatin |
| Which platinum based chemotherapy agent associated with higher incidence of nephrotoxicity? | cisplatin |
| Which platinum based chemotherapy agent associated with higher incidence of ototoxicity? | cisplatin |
| Which platinum based chemotherapy agent associated with higher incidence of dose-dependent myelosuppression? | carboplatin |
| Which platinum based chemotherapy agent associated with higher incidence of acute sensory neuropathy exacerbate with cold ? | oxaliplatin |
| What are some consideration to minimize the risks of cisplatin induced nephrotoxicity ? | - cap cisplatin dose to 100mg/m2 PER CYCLE - hydration prior to each dose with IV 1-2 L - Amifostine: chemoprotectant |
| What are some common monitoring parameters of cisplatin induced nephrotoxicity? | - RENAL FUNCTION: intake = output - Mg & K - Hydration |
| What are some common monitoring parameters of cisplatin induced ototoxicity? | - audiograms 1- baseline 2- each dose |
| What is the CINV classification of Cisplatin? | HIGH emetogenic -----> use 3-4 drugs |
| What is the dosing method of Carboplatin? | Carboplatin doses based on Targeted AUC |
| What is the dosing formula of carboplatin? | - calvert formula total carboplatin dose (mg) = AUC X (GFR +25) - GFR: capped at 125ml/min - AUC: 2-8 mg/ml X min |
| What is an important counseling point for patient receiving Oxaliplatin? | - onset of acute sensory neuropathy - 1-7days after chemo - AVOID COLLLLLD |
| When is the use of cisplatin C/I? | - myelosuppression - renal impairment - hearing impairment |
| when is the use of Carboplatin C/I? | - myelosuppresion |
| Which platinum based compounds causes myelosuppresion? (BBW) | cisplatin carboplatin |
| which platinum based compounds causes renal toxicity? (BBW) | - cisplatin |
| which platinum based compounds causes ototoxicity? (BBW) | - cisplatin |
| which platinum based compounds after the 6th cycle associated with anaphylactic like reaction ? (BBW) | - Carboplatin ( after the 6th cycle) |
| which platinum based compounds has minimum CINV? | oxaliplatin |
| which platinum based compounds have the highest CINV? | cisplatin |
Created by:
Smoham38
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