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Oncology II
Non-Specific Cell Cycle Cytotoxic Drugs: Alkylating Agents
| Term | Definition |
|---|---|
| What are common non- specific cell cycle cytotoxic agnets? | - Anthracylcines - Platinum agents - Alkylating agents |
| What are common specific cell cycle cytotoxic agents? | - based on the cell cycle phase |
| What are some common targeted chemotherapies( recognized specific biomarkers? | - TKIs - Monoclonal Ab |
| What is the MOA of Alkylating agent? ( introduce alkyl radical ) | - cross linking DNA strands ----> inhibits protein synthesis and DNA synthesis |
| what is some possible off -target outcomes of using alkylating agent? | DNA mutation --> 2nd malignancies ( acute leukemia) |
| what is the proposed MOA of Ifosfamide and cyclophosphamide toxicity ( hemorrhagic cystitis? | - build up of the active metabolites ( acrolein) |
| What is the management approach in ifosfamide/cyclophosphamide induced hemorrhagic cystitis? | - hydration - mesna chemo-protective |
| what is an important consideration while using Carmustine? | - non PVC bag/tube |
| what is an important consideration while using Dacarbazine ? | light sensitive ( decompose pink) |
| what is an important consideration while using procarbazine? | avoid MOA inhibitor |
| what is an important consideration while using Lomustine? | avoid more than ONE dose / 6 weeks 2/2 overdosed fatal toxicity |
| BBW of all alkylating agents? | myelosuppression |
| Which drug BBW of hemorrhagic cystitis? | Ifosfamide and cyclophosphamide --- BBW |
| which drug BBW of pulmonary toxicities ? | carmustine ---BBW |
| which drug BBW of neurotoxicity? | Ifosfamide --BBW |
| Which drug BBW of hepatic necrosis? | dacarbazine --BBW |
| which alkylating agent causes pulmonary toxicity ( side effect) vs. pulmonary toxicity ( BBW) ? | BBW: carmustine side effect: carmustine, lomustine, busulfan |
| which alkylating agent causes pulmonary fibrosis ? | carmustine, lomustine, busulfan |
| which alkylating agent causes Syndrome of inappropriate antidiuretic hormone (SIADH)? | cyclophosphamide |
| what is the classification of alkylating agent in trem of CINV? | moderate- high emetogenic |
| what are some common side effects of alkylating agents? | - alopecia - mucositis - 2nd malignancies - nephortoxicity |
| which alkylating agent causes hepatotoxicity? | bendamustine |
| which alkylating agent causes hepatotoxicity vs. hepatic necrosis ( BBW)? | bendamustine vs. dacarbazine |
| The use of alkylating agents causes reactivation of of which infections? | - CMV - TB - HCV - HBV |
| List the common alkylating agents? | phosphamide: cyclophosphamide and ifosfamide , temozolomide Mustine: carmustine, lomustine, bendamustine Carbazine: dacarbazine and procarbazine amine: altretamine and mechlorethamine an: Busulfan, melphalan |
Created by:
Smoham38
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