Save
Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Oncology 1-V

Clinical Recap of Chemotherapy Side Effects

TermDefinition
Which chemo therapeutic drugs have the min risk of inducing myelosuppression? - asparaginase - bleomycin - Vincristine - Monoclonal/ TKIs ( cristine with mycie - eat asparagly)
What are some lab parameters to monitor myelosuppression? - CBC - Temp ( febrile neutropenia) - SOB, fatigue ( anemia) - bleeding ( thrombocytobina)
Drug of choice to tx neutropenia? CSF
drug of choice to tx anemia? - transfusion - ESA
drug of choice is tx thrombocytopenia? platelet transfusion
Which chemo agents are highly emetogenic ? C2DEF - cisplatin - doxorubicin/epirubicin - cyclophosphamide - ifosfamide
drug of choice for CINV? - 5-HT-3 blocker - neurokinin-1 receptor blocker - dexamethasone - IV/PO fluid ( volume depletion)
Which chemo agents induce mucositis? Mouth irritated with fluorouracil and nib - mexthotrexate - fluorouracil, capecitabine - irinotecan - TKIs: 1- afatinib 2- ponatinib 3- sorafenib - sunitinib
drug of choice of chemo induced mucositis? - mucosal coating - anesthetics
what are some complications of mucositis ( monitor during therapy)? - herpes simplex virus - fungal ( candida species)
which chemo agents induce diarrhea? - fluorouracil, capecitabine - irinotecan - sorafenib - sunitinib
what are some complication associated with chemo induced diarrhea ( monitor during therapy? - volume depletion - potassium/ electrolyte level - bowel movement
drug of choice for chemo induced diarrhea? - anti motility drugs
drug of choice for acute onset diarrhea ? in particular with irinotecan use? - atropine ( acute ) IV/PO hydration
drug of choice for delayed onset diarrhea? - loperamide - IV/PO hydration
which chemo drug causes constipation? - vincristine - pomalidomide - thlidomide ( cristine domide)
drug of choice for chemo induced constipation? - PEG ( stimulant)
what chemo regimen causes xerostomia? - radiation therapy of head/neck
drug of choice for chemo induced xerostomia? pilocarpine
what are the two main types of chemo induced cardiotoxicity? - cardiomyopathy - QT prolongation
Which chemo drugs cause cardiomyopathy? - anthracyclines ( rubicin family) - fluorouracil - lapatinib - HERS (-) ( stuzumab family): 1- adotrastuzumab 2- trastuzumab 3- pertuzumab
what are the common anthracycline drugs ? RUBICIN FAMILY Daunorubicin. Doxorubicin. Epirubicin. Idarubicin. Mitoxantrone. Valrubicin
what are monitoring parameters for cardiomyopathy? - LVEF - cumulative dose of anthracyclines
what is the recommended cumulative dose of anthracyclines to prevent/min risk of chemo induced cardiomyopathy? - doxorubicin: 440-550 mg/m2 life time
drug of choice as prophylaxis for doxorubicin induced cardiomyopathy? - dexrazonxane
which drugs cause QT prolongation? 1- arsenic trioxide 2- TKI (inib & enib) 3- leuoprolide
What are monitoring parameters for QT prolongation? - heart electrolyte 1- Mg, 2- Ca 3- K 4- ECG
WHEN chemo therapy should be held? if QTc> 500 msec --- prolonged
which drugs causes pulmonary fibrosis? carlomu- mycne busu - bleomycine - busulfan - carmustine - lomustime
what are monitoring parameters for pulmonary fibrosis? - oxygen - ABGS ( atrial blood gas) - SOB
what is the management of chemo induced pulmonary fibrosis? - stop the drug - as prevention keep bleomycin max life dose of 400mg IU
which drugs cause pulmonary pneumonitis? mexthotrexate MC AB 1- atezolizumab 2- ipilimumab 3- nivolumab 4- pembrolizumab
which chemo drugs induce hepatotoxicity? - 4 main class of drugs: 1- anti-androgens 2- folate anti metabolites 3- pyrimidine analog antimetabolites ( cytarabine and gemcitabine) 4- TKI inhibitors
what are the common anti androgens chemo drugs that induce hepatotoxicity? amide 1- bicalutamide, 2- flutamide, 3- nilutamide)
what are the common folate anti metabolites chemo drugs that induce hepatotoxicity? trexate 1- methotrexate, 2- pemetrexed 3- prallatrexate
what are the common Pyrimidine analog antimetabolites that induce hepatotoxicity? abine 1- cytarabine 2- gemcitabine)
what are the common TKI induce hepatotoxicity? 1- ipilimumab 2- pembrolizumab 3- nivolumab 4- atezolizumab
what are some common monitoring parameters for hepatotoxicity? 1- LFT 2- Jaundice 3- Ascites
what is the recommended management of chemo induced hepatotoxicity ? - stop tx - steroid if the hepatotoxicity is induced by TKI that targets PD-1
which chemo drugs induce nephrotoxicity? - cisplatin and carbaplatin - methotrexate ( high dose), pemetrexed, pralatrexate - other: 1- carflizomib 2- bevacizumab 3- nivolumab 4- pembrolizumab 5- ipilimumab 6- atezolizumab -
what are some common monitoring parameters for nephrotoxicity? - BUN - SCr - urinalysis - urine output - CrCl
what is the recommendation to manage cisplatin induced nephrotoxicity? - hydration - max dose of cisplatin 100mg/m2 /cycle - amifostine ( Ethyol prophylactic)
which chemotherapeutic agents induce hemorrhagic cystitis? - ifosfamide ( all doses ) - cyclophosphamide ( high dose >1 gram/m2)
what is the recommendation to manage ifosamide induced hemorrhagic cystitis? - Mesna prophylactically - hydration
what are the two common forms of chemo induced neuropathy? - peripheral sensory neuropathy - autonomic neuropathy
which chemo drugs induce peripheral sensory neuropathy? - vinca alkaloids: vincrisine,vinblastine,vinorelbine - platinums:cisplatine,oxaliplatin - taxanes: paclitaxel, docetaxel, cabazitaxel
which chemo drugs induce peripheral sensory neuropathy? - proteasome inhibitors: : bortezomib, carflizomib - thalidomide, cytarabine high dose brentuximab - ado trastuzumab
which chemo drugs induce autonomic neuropathy? - vinca alkaloids
what are some management step to reduce the risk of vincristine induced peripheral neuropathy? - limit the dose of vincristine to 2 mg/week - cap at 2 mg /week
which drug causes acute cold mediated sensory neuropathy? oxaliplatin
which forms of administration of brotezomib associated with less peripheral neuropathy risk? - SC
which chemotherapy induce thromboembolic risk? - aromatase inhibitors: ( trazole) - serms ( tamoxifen) - immunomodulators ( thalidomide, lanalidomide, pomalidomide)
what are some common monitoring parameters for thromboembolic ? - dvt - pe - stroke - MI
Created by: Smoham38
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards