Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Oncology 1-V
Clinical Recap of Chemotherapy Side Effects
| Term | Definition |
|---|---|
| Which chemo therapeutic drugs have the min risk of inducing myelosuppression? | - asparaginase - bleomycin - Vincristine - Monoclonal/ TKIs ( cristine with mycie - eat asparagly) |
| What are some lab parameters to monitor myelosuppression? | - CBC - Temp ( febrile neutropenia) - SOB, fatigue ( anemia) - bleeding ( thrombocytobina) |
| Drug of choice to tx neutropenia? | CSF |
| drug of choice to tx anemia? | - transfusion - ESA |
| drug of choice is tx thrombocytopenia? | platelet transfusion |
| Which chemo agents are highly emetogenic ? C2DEF | - cisplatin - doxorubicin/epirubicin - cyclophosphamide - ifosfamide |
| drug of choice for CINV? | - 5-HT-3 blocker - neurokinin-1 receptor blocker - dexamethasone - IV/PO fluid ( volume depletion) |
| Which chemo agents induce mucositis? Mouth irritated with fluorouracil and nib | - mexthotrexate - fluorouracil, capecitabine - irinotecan - TKIs: 1- afatinib 2- ponatinib 3- sorafenib - sunitinib |
| drug of choice of chemo induced mucositis? | - mucosal coating - anesthetics |
| what are some complications of mucositis ( monitor during therapy)? | - herpes simplex virus - fungal ( candida species) |
| which chemo agents induce diarrhea? | - fluorouracil, capecitabine - irinotecan - sorafenib - sunitinib |
| what are some complication associated with chemo induced diarrhea ( monitor during therapy? | - volume depletion - potassium/ electrolyte level - bowel movement |
| drug of choice for chemo induced diarrhea? | - anti motility drugs |
| drug of choice for acute onset diarrhea ? in particular with irinotecan use? | - atropine ( acute ) IV/PO hydration |
| drug of choice for delayed onset diarrhea? | - loperamide - IV/PO hydration |
| which chemo drug causes constipation? | - vincristine - pomalidomide - thlidomide ( cristine domide) |
| drug of choice for chemo induced constipation? | - PEG ( stimulant) |
| what chemo regimen causes xerostomia? | - radiation therapy of head/neck |
| drug of choice for chemo induced xerostomia? | pilocarpine |
| what are the two main types of chemo induced cardiotoxicity? | - cardiomyopathy - QT prolongation |
| Which chemo drugs cause cardiomyopathy? | - anthracyclines ( rubicin family) - fluorouracil - lapatinib - HERS (-) ( stuzumab family): 1- adotrastuzumab 2- trastuzumab 3- pertuzumab |
| what are the common anthracycline drugs ? RUBICIN FAMILY | Daunorubicin. Doxorubicin. Epirubicin. Idarubicin. Mitoxantrone. Valrubicin |
| what are monitoring parameters for cardiomyopathy? | - LVEF - cumulative dose of anthracyclines |
| what is the recommended cumulative dose of anthracyclines to prevent/min risk of chemo induced cardiomyopathy? | - doxorubicin: 440-550 mg/m2 life time |
| drug of choice as prophylaxis for doxorubicin induced cardiomyopathy? | - dexrazonxane |
| which drugs cause QT prolongation? | 1- arsenic trioxide 2- TKI (inib & enib) 3- leuoprolide |
| What are monitoring parameters for QT prolongation? | - heart electrolyte 1- Mg, 2- Ca 3- K 4- ECG |
| WHEN chemo therapy should be held? | if QTc> 500 msec --- prolonged |
| which drugs causes pulmonary fibrosis? carlomu- mycne busu | - bleomycine - busulfan - carmustine - lomustime |
| what are monitoring parameters for pulmonary fibrosis? | - oxygen - ABGS ( atrial blood gas) - SOB |
| what is the management of chemo induced pulmonary fibrosis? | - stop the drug - as prevention keep bleomycin max life dose of 400mg IU |
| which drugs cause pulmonary pneumonitis? | mexthotrexate MC AB 1- atezolizumab 2- ipilimumab 3- nivolumab 4- pembrolizumab |
| which chemo drugs induce hepatotoxicity? | - 4 main class of drugs: 1- anti-androgens 2- folate anti metabolites 3- pyrimidine analog antimetabolites ( cytarabine and gemcitabine) 4- TKI inhibitors |
| what are the common anti androgens chemo drugs that induce hepatotoxicity? amide | 1- bicalutamide, 2- flutamide, 3- nilutamide) |
| what are the common folate anti metabolites chemo drugs that induce hepatotoxicity? trexate | 1- methotrexate, 2- pemetrexed 3- prallatrexate |
| what are the common Pyrimidine analog antimetabolites that induce hepatotoxicity? abine | 1- cytarabine 2- gemcitabine) |
| what are the common TKI induce hepatotoxicity? | 1- ipilimumab 2- pembrolizumab 3- nivolumab 4- atezolizumab |
| what are some common monitoring parameters for hepatotoxicity? | 1- LFT 2- Jaundice 3- Ascites |
| what is the recommended management of chemo induced hepatotoxicity ? | - stop tx - steroid if the hepatotoxicity is induced by TKI that targets PD-1 |
| which chemo drugs induce nephrotoxicity? | - cisplatin and carbaplatin - methotrexate ( high dose), pemetrexed, pralatrexate - other: 1- carflizomib 2- bevacizumab 3- nivolumab 4- pembrolizumab 5- ipilimumab 6- atezolizumab - |
| what are some common monitoring parameters for nephrotoxicity? | - BUN - SCr - urinalysis - urine output - CrCl |
| what is the recommendation to manage cisplatin induced nephrotoxicity? | - hydration - max dose of cisplatin 100mg/m2 /cycle - amifostine ( Ethyol prophylactic) |
| which chemotherapeutic agents induce hemorrhagic cystitis? | - ifosfamide ( all doses ) - cyclophosphamide ( high dose >1 gram/m2) |
| what is the recommendation to manage ifosamide induced hemorrhagic cystitis? | - Mesna prophylactically - hydration |
| what are the two common forms of chemo induced neuropathy? | - peripheral sensory neuropathy - autonomic neuropathy |
| which chemo drugs induce peripheral sensory neuropathy? | - vinca alkaloids: vincrisine,vinblastine,vinorelbine - platinums:cisplatine,oxaliplatin - taxanes: paclitaxel, docetaxel, cabazitaxel |
| which chemo drugs induce peripheral sensory neuropathy? | - proteasome inhibitors: : bortezomib, carflizomib - thalidomide, cytarabine high dose brentuximab - ado trastuzumab |
| which chemo drugs induce autonomic neuropathy? | - vinca alkaloids |
| what are some management step to reduce the risk of vincristine induced peripheral neuropathy? | - limit the dose of vincristine to 2 mg/week - cap at 2 mg /week |
| which drug causes acute cold mediated sensory neuropathy? | oxaliplatin |
| which forms of administration of brotezomib associated with less peripheral neuropathy risk? | - SC |
| which chemotherapy induce thromboembolic risk? | - aromatase inhibitors: ( trazole) - serms ( tamoxifen) - immunomodulators ( thalidomide, lanalidomide, pomalidomide) |
| what are some common monitoring parameters for thromboembolic ? | - dvt - pe - stroke - MI |
Created by:
Smoham38
Popular Pharmacology sets