Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Oncology I-III
Oncology Side Effects & GI Complications
| Term | Definition |
|---|---|
| what are the three common chemo induced gastrointestinal complications? | 1- damage to epithelium of the GI track --> diarrhea 2- damage to oral mucosal epithelium --> mucositis 3- damage to the salivary glands --> xerostomia |
| What are the common complications of chemo induced diarrhea CID? | 1- dehydration 2- electrolyte imbalance |
| What are the drug(s) of choice to treat chemo induced diarrhea? | 1- loperamide 2- diphenoxylate + atropin |
| what is the different in loperamide dosing in CID? | - usual max dose of loperamide is 16 mg/day - in CID max is 24 mg/day |
| What are some COMMON chemo agents that cause DELAYED CID? | - fluorouracil - capecitabine |
| What is the main factor that increases the risk of CID while using fluorouracil and capecitabine? | - leucovorin - pt has DPD deficiencies |
| what is a common chemo agent that cause acute onset of CID? | - irrinotecan - during the infusion combined with cholinergic sxs |
| what is the recommended treatment of irrinotecan induced diarrhea and cholinergic sxs? | - anti cholinergic drug 1- benzoatropine 2- diphenhydramine |
| what are chemo class that commonly cause diarrhea? | - VEGFR - EGFR 1- sorafenib 2- sunitinib |
| what is the common drug caues CID? | - fluorouracil - capecitabine - irrinotecan - VEGFR - EGFR |
| what is the onset of oral mucositis ? | - peaks after a week - resolves within 4-8 days |
| what is the recommended prevention of chemo induced mucositis? | - NO RECOMMENDATION |
| what are some complications a patient with oral mucositis may experience ? | - herpes simplex virus - candida spp |
| what is the recommendation for oral pain and discomfort in patient with chemo induced oral mucositis? | - mucosal barrier - anesthetic |
| what are some mucosal barrier medications ? | - mucosal barrier: 1- gel 2- spray 3- solution 4- wafer |
| what are some anesthetic drug to treat chemo induced mucositis pain ? | - lidocaine 2% solution |
| what are some common side effects of mucosal barrier? | - burning - stinging sensation |
| what is the recommended dose of lidocaine 2% solution in chemo induce mucositis oral pain? | 15 ml wish/ spit every 3 hrs PRN |
| Why the use of lidocaine 2% solution is not recommended ( avoided BBW) in patients 3 years old or younger? | - seizure risk - cardiopulmonary arrest - death |
| what are some serious side effects of high dose lidocaine 2% solution? | - high plasma level--> seizure and cardiopulmonary arrest |
| what are some of the lidocaine 2% solution side effects? | - dizziness - drowsiness - confusion - hypotension |
| what are some of the recommendation a patient should follow if taking lidocaine 2%? | - avoid ingestion for 60 min 2/2 swallowing and aspiration impairment |
| what is the recommended treatment in chemo induced xerostomia? | - artificial saliva substituent - pilocarpine |
| which xerostomia drug requires dose adjustment in patient with hepatic impairment? | - Pilocarpine - 5-10 mg/3X --> 5mg/2X - Avoid in SEVERE impairment - AVOID GIVEN with HIGH FAT meal |
| what are some common side effect of pilocarpine ? | - cholinergic 1- flushing 2- sweating 3- nausea 4- urinary frequency |
| which disease states require caution of using pilocarpine? | - CV - Respiratory ( COPD and asthma) - GI-stones ( choleithiasis and nephrolithiasis ) |
Created by:
Smoham38
Popular Pharmacology sets