Busy. Please wait.
or

show password
Forgot Password?

Don't have an account?  Sign up 
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
Know
remaining cards
Save
0:01
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Injectable DM

Injectable DM Drugs GLP-1 and Pramlintide

QuestionAnswer
What is the MOA of GLP-1 agonist? - analogues of GLP-1 - increases the glucose dependent insulin secretion
Which GLP-1 agonist are NOT recommended in pt with CrCL < 30 or ESRD? exenatide ( byetta) and Exenatide extended release ( bydureon)
Which GLP-1 agonist are dosed once every WEEK? - Exenadtide extended release - Dulaglutide - Albiglutide
Which GLP-1 agonist DO NOT increases the risk of Thyroid C-Cell carcinomas? - Byetta ( extentide) and Adlyxin ( Lixisenatide)
When GLP-1 agonist are considered C/I? - ALL GLP-1 agonist increase the risk of Thyroid C cell carcinoma except Byetta and Adlyxin 1- Pt with h/o of medullary thyroid carcinoma 2- pt with endocrine neoplasia syndrome type II
When GLP-1 agonist is not recommended? in pt with severe GI diseases
What are some of the GLP-1 agonist warnings? - pancreatitis ( h/o pancreatitis, EtOH use, gallstones, increased TG)
Which GLP-1 agonist has increased risk of injection site reaction such as abscess, cellulitis and necrosis? Bydureon -- Extenatide extended releases
Which GLP-1 agonist has increased risk of Cardiovascular effects such as tachycardia, 1st degree AV block and PR interval prolongation? -Trulicity ( Dulaglutide)
What are some of GLP-1 agonist side effects? - NAUSEA common effect - Wt LOSS - vomiting, D, constipation, hypoglycemia - injection site reaction
What are the common monitoring parameters while pt on GLP-1 agonist? - Renal function - A1c and BG
Which GLP- 1 agonist should be taken within 60 min of meals? - Byetta ( exenatide) and Adlxin ( lixisenatide)
What is the proposed MOA of DDI in pt taking GLP-1 agonist? - GLP-1 can slow gastric emptying --> REDUCE extend/ rate of absorption - Caution if narrow therapeutic drugs are used ( as threshold conc of efficacy is required)
When should the patient on GLP-1 agonist be advised to take oral contraceptive? - 1 hr before exenadtide and Adlyxin - 8 hr after Adlyxin
What are the main point to counsel pt using GLP-1? - SC injection - Rotate sites - dispose needle, pen and syringes in sharp containers
what is the dosing of Byetta ( exenatide)? - 2X/day - 60 min with in the meal time - NEVER Inject after a meal - GOOD for 30 days ONLY
What is the dosing of Bydureon ( extenatide extended release)? - ONCE/week - single-dos vital/tray formula --> once mixed --> inject - pen formula --> refrigerator
What is the dosing of Tanzeum ( albiglutide)? - pen formula --> powder + water --> needs mixing - needs refrigerator - after mixing the solution is clear and slightly yellow
What is the recommendations if pt misses a dose of the following medications: Bydureon, trulicity and tanzeum? - these dosed once/week - missed dose take ASA you remember as long as the next dose is not < 3 days
What is the the dosing of Adlyxin ( Lixisenatide)? - once/day within 60 min of the 1st meal ( similar to byetta) - it's 14 days supply - it comes as starter pack ( green / 10 mcg/dose) and continuous pack ( burgundy 20 mcg/dose) -
What is the MOA of Pramlintide? - it's a synthetic analog of Amylin ( neuroendocrine hormone produced by beta cells) - targets PPBG - slows down the gastric emptying, suppress glucagon
When Pramlintide ( symlin) is C/I? - in pt with gastroparesis - Unawarness hypoglycemia
Which class of drugs increases the risk of severe hypoglycemia in pt taking Pramlintide (symlin) and considered BBW as combination ? - insulin within 3 hrs - severe hypoglycemia is BBW when used with insulin - consider 50% reduction of mealtime insulin when starting Pramlintide
What are some of the common side effects of pramlintide? - GI : n/v/ anorexia/ wt loss - headache
What is the pramlintide ( symlin) dosing in type I and II DM pt? - type I: symlin pen 60 mcg/dose - type II: symlin pen 120 mcg/dose ** NAUSEA: is the titration factor **
What is the required major meal nutrients prior to SC administration of Pramlintide? - SC in thigh or abdominal area prior to meal - >250 Kcal - > 30 grams carbs *** if the meal doesn't meet these requirements, skip the dose 2/2 to severe hypoglycemia side effect
What is the proposed MOA of DDI with pramlintide? - slows gastric emptying --> reduces rate/extent of absorption - administer other drugs 1 hr before or 2 hr after
Created by: Smoham38