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Table 10.1
Centrally Acting Muscle Relaxants
| Generic | Brand | Dosage Form | Route of Administration | Common Dose |
|---|---|---|---|---|
| Cyclobenzaprine hydrochloride | (Flexeril) | Tablet, extended-release (ER) capsule | Oral | Tablet: 5-10 mg 3 times a day ER capsules: 15-30 mg a day |
| Metaxalone | (Skelaxin) | Tablet | Oral | 800 mg 3 times a day |
| Methocarbamol | Robaxin | Tablet, injectable solution | Oral, IM, IV | PO: 750-1,500 mg 3-4 times a day IM/IV: 1,000 mg (maximum infusion rate of 300 mg/min may be repeated every 8 hours as needed) |
| Orphenadrine citrate | Norflex | Tablet, ER tablet, injectable solution | Oral, IM, IV | PO: 100 mg 2 times a day in morning and evening IM/IV: 60 mg, may be repeated every 12 hours as needed |
| Tizanidine (Zanaflex) | (Zanaflex) | Tablet, capsule | Oral | 4-8 mg every 6-8 hours |
| Baclofen | Lioresal | Tablet, oral solution, intrathecal (IT) solution | Oral, IT | PO: 20-80 mg/day in divided doses 3-4 times a day IT: 90-800 mcg/day via continuous infusion pump |
| Carisoprodol | Soma | Tablet | Oral | 250-350 mg 3 times a day and bedtime |
| Chlorozoxazone | Paraflex, Parafon Forte | Tablet | Oral | 250-750 mg 3-4 times a day |