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Anxiety & PD 411

Anxiety and Panic Disorders

QuestionAnswer
Anxiety 3 Neuro-chemical theories Noradrenergic Model (hypersensitive ANS), Benzodiazepine Receptor Model (inhibitory pathway deficit, can't calm down), Serotonin Model (inhibitory NT, may help reduce ANS hyperactive state)
Most effective and safe meds for ACUTE anxiety symptoms Benzodiazepines
Benzodiazepines ADRs CNS depression, anterograde amnesia, dependence, w/drawal
BZDs w/ rapid onset of action Diazepam & Clorazapate (0.5-1hr)
BZDs w/ slow onset of action Lorazapam & Oxasepam (2-4 hrs)
Benzodiazepines drugs Alprazolam, Clonazapam, Chlordiazepoxide, Clorazepate, Diazepam, Halazepam, Lorazepam, Oxazepam
Buspirone ADRs No sedation, no abuse potential, dizziness, HA, nausea
Buspirone Onset 1 week
Buspirone Max effect 4-6 weeks
When to use Buspirone chronic, persistent anxiety
When to use Antidepressants for anxiety first line for long term management of GAD. Effective w/ comorbid depression
Antidepressants for anxiety Onset delayed, 2-4 weeks
Beta-blockers for anxiety most effective when: prominient cardiovascular symptoms accompany GAD (stage fright)
First Line therapy for Panic Disorder SSRI's
SSRI's for PD ADRs GI upset, weight gain, sexual dysfunction, w/drawal
SSRI's for PD onset Delayed, 3-5 wks, up to 8-12 wks
TCA's for PD drugs Imipramine
MAOI's for PD Reserved for treatment refractory pts b/c of ADRs & interactions
BZDs for PD Onset Rapid
BZDs for PD ADRs w/drawal, CNS depression, dependence, anterograde amnesia, abuse potential
Imipramine TCA’s for PD drugs
Diazepam & Clorazapate BZDs w/ rapid onset of action
Lorazapam & Oxasepam BZDs w/ slow onset of action
Created by: lbreimeir
Popular Pharmacology sets

 

 



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