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MCRT Bronchospasm

Biochemistry of Bronchospasm

Name the 2 parts of the autonomic nervous system that influence the bronchial smooth muscle tone Sympathetic and Parasympathetic nervous system
Name the two nucleotides that influence bronchial smooth muscle tone cAMP, cGMP
cAMP is responsible for..... bronchodilation
cGMP is responsible for .... bronchoconstriction
List 3 mechanisms of bronchodilation 1) Adenyl cyclase activation, 2) Prevention of guanyl cyclasee activation, 3) PDE inhibition
What occurs when the beta-2 receptor is stimulated? Adenyl Cyclase Activation
What is the result of Adenyl Cyclase Activation? Bronchodilation
What occurs when the alpha receptor is activated? Guanyl Cyclase Activation
What is the result of Guanyl Cyclase activation? Bronchospasm
What is the result of blocking the alpha receptor? Prevention of Bronchospasm
What occurs when the cholinergic receptor is activated? Guanyl Cyclase activation
What is the result of blocking the cholinergic receptor? Prevention of Bronchospasm
What is the role of Phosphodiesterase (PDE)? Deactivates cAMP, Metabolizes cAMP to 5'AMP
What occurs when PDE is inhibited? The life of cAMP is extended resulting in bronchial relaxation for a longer period of time.
Draw and label the bronchial smooth muscle cell including receptors and sequence of events that occurs within the cell. see page 558
What role does the mast cell play regarding bronchial smooth muscles tone? When degranulated the mast cell releases mediator agents that can cause bronchospasm.
List the mediators released after degranulation of the mast cell. Histamine, prostaglandins, serotonin, bradykinin, leukotrienes, ECF-A
List 3 medications that stimulate the beta-2 receptor. Albuterol, Pirbuterol, Terbutaline
List 2 Long-acting beta-2 stimulants. Salmeterol, Formoterol
List 3 medications used for cholinergic blockade. ipratropium bromide, oxytropium bromide, tiotropium bromide
List 3 leukotriene modifers Zafirlukast, Montelukast, Zileuton
List 2 mast cell stablizers (blick the antigen-antibody reaction cromolyn sodium, Nedocromil
What group of medications is responsible for PDE inhibition? methylxanthines
List 3 methylxanthines. caffeine, theobromide, theophylline (aminophylline is the liquid form of theophylline)
Which mediation prevents the IgE from attaching to the mast cell? Xolair
What is the mode of action for Roflumilast? PDE inhibition
Created by: smiddleton