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Diabetic Agents

DrugClass, Dose, SE
Metformin (Diabex) Biguanide Type 2 Diabetes, also used for fertility in patients with polycystic ovary syndrome Dose IR: 500mg- 1000mg tid Max 3g XR: 500mg to 1000mg bd Max 2g GI side effects
Glibenclamide (Daonil/Glimel) Sulfonylurea - increases pancreatic insulin secretion 2.5mg to 20mg 1-2 times daily. Split doses over 10mg. Hypoglycaemia and weight gain
Gliclazide (Diamicron) Sulfonylurea - increases pancreatic insulin secretion IR: 40mg-320mg daily in 1-2 doses. Maximum 120mg/dose. XR: 30mg-120mg in 1-2 doses. Hypoglycaemia and weight gain
Glimepiride (Amaryl) Sulfonylurea - increases pancreatic insulin secretion 1mg-4mg daily. Hypoglycaemia and weight gain
Glipizide (Melizide/Minidab) Sulfonylurea - increases pancreatic insulin secretion 2.5mg to 40mg daily. Hypoglycaemia and weight gain
Pioglitazone (Actos) Glitazone 15mg-30mg daily Max 45mg Peripheral oedema, weight gain, headache, dizziness
Rosiglitazone (Advandamet + Metformin) Glitazone 2mg-4mg daily. Peripheral oedema, weight gain, headache, dizziness
Alogliptan (Nesina) DPP-4 Inhibitor 6.12, 12.5 or 25mg daily. GORD, itch, hypoglycaemia (mostly when combo with S or insul) headaches, joint pain
Linagliptan (Trajenta) DPP-4 Inhibitor 5mg daily Hypoglycaemia (mostly when combo with S or insul) headaches, joint pain
Saxagliptan (Onglyza) DPP-4 Inhibitor 2.5-5mg daily GI side effects, hypoglycemia (mostly when combo with S or insul) headaches, joint pain
Sitaglipan (Januvia) DPP-4 Inhibitor 25mg, 50mg, 100mg daily Nausea, hypoglycaemia (mostly when combo with S or insul) headaches, joint pain
Vildagliptan (Galvus) DPP-4 Inhibitor 50mg daily Dizziness, peripheral oedema, hypoglycaemia (mostly when combo with S or insul) headaches, joint pain
Exenatide (Byetta + Bydureon) Glucagon-Like Peptide-1 Analogue Byetta 5mcg twice a day within 60 minutes of meals Bydureon 2mg once a week Headache, dizziness, feeling jittery
Liraglutan (Saxenda) Glucagon-Like Peptide-1 Anglogue 0.6mg once daily, increasing in increments of 0.6mg every week to a maximum of 1.8mg. GI side effects
Empagliflozin (Jardiance) Sodium-Glucose Co-Transporter-2 Inhibitors (SGLT-2) 10mg-25mg daily Genital infections, dehydration, polyuria, monitor renal function
Dapagliflozin (Forxiga) Sodium-Glucose Co-Transporter-2 Inhibitors (SGLT-2) 10mg daily Genital infections, dehydration, polyuria, monitor renal function
Created by: zoeydaphne
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