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Clinical Trials ACS

QuestionAnswer
ISIS-2 All reduce mortality ASA beneficial
ISG Alteplace (tPA) More stroke and intracranial hemmorage, Streptokinase Increase bleed
ISIS-3 Duteplace (tPA) increase in stroke, Heparin increase bleeding
Gusto Alteplace(tPA) +streptokinase increase risk in bleed, Study flawed
Gusto III Alteplace (tPA) and receteplace (rPA) not statistically different in mortality or stroke
Assent-2 Tenecteplace (TNK) Fewer bleeding complications, less specificity, increase in intranial bleed and stroke.
Gusto V Recelplace (rPA)+abciximab +heparin Increase risk for bleed
Assent-3 Combination of lower dose, decrease mortality, reinfarct
EPIC Abciximab 60% reduction in mortality, 13% 3 year reduction
EPILOG Combo Abciximab+low dose weight LMWH adjusted decreases bleeding
PRISM Alone Tirofiban increase mortality, Combo Tirofiban, heparin reduce in mortality
PURSUIT All epitifibatide were significantly better than placebo
ESPIRIT Eptifibatide + IIb/IIIa inhibitor decreases mortality risk 47%
Gusto-IV Abciximab best with 24hour infusion
Created by: liza001
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