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Exam 2 drugs
| Question | Answer |
|---|---|
| The key function of Botulinum Toxin | Prevents release of Acetylcholine |
| Botulinum Toxin's mechanism of action | Inhibits release of Acetylcholine by degrading synaptobrevin (SNARE), which prevents vesicle fusion / exocytosis |
| Used to obtain miosis after delivery of the lens in cataract surgery and other procedures where rapid miosis is required | Acetylcholine |
| Muscarinic and nicotinic agonist | Acetylcholine |
| Muscarinic agonist for postoperative urinary retention. Atony of the urinary bladder | Bethanechol |
| Muscarinic agonist used for diagnosis of bronchial airway hyperreactivity in subjects who do not have clinically apparent asthma. | Methacholine |
| Partial muscarinic agonist for Glaucoma and treatment of dry mouth due to radiotherapy for cancer of head and neck | Pilocarpine |
| Agonist at nicotinic receptors depolarizes autonomic ganglia, resulting first in stimulation and then in paralysis. | Nicotine |
| Ganglionic stimulation by depolarization. The response resembles simultaneous discharge of both parasympathetic and sympathetic nervous systems | Nicotine Low dose |
| ganglionic blockade and neuromuscular blockade | Nicotine High dose |
| Anti-Cholinesterase that Does Not enter CNS. used for the diagnosis of myasthenia gravis: leads to rapid increase in muscle strength. Also used to reverse the neuromuscular block produced by non-depolarizing muscular blockers. | Edrophonium |
| Anti-Cholinesterase that Can enter and stimulate CNS. Used for the treatment of overdoses of anticholinergic drugs. | Physostigmine |
| Anti-Cholinesterase that Does Not enter CNS. used for Urinary retention. Reversal of effects of non-depolarizing neuromuscular blockers after surgery. Treatment of myasthenia gravis | Neostigmine |
| Anticholinesterase that Does Not enter CNS. used solely for the treatment of myasthenia gravis, | Pyridostigmine |
| Irreversible Anticholinesterase. irreversibly bind to active portions of AChE to form an extremely stable complex, which prevents ACh breakdown. causes muscle paralysis and death (Insecticide) | Malathion |
| Organophosphate. Among the most potent synthetic toxic agents known. (nerve agent) | Sarin |
| muscarinic antagonist Reversible competitive antagonist at muscarinic receptors. Tertiary amine: both central and peripheral muscarinic blocker. | Atropine |
| M3 blockade for eye, GI, urinary system, secretions, and atrial M2 blockade for CV system. Antidote for cholinergic agonists. blocks respiratory tract secretions prior to surgery | Atropine |
| Muscarinic receptor antagonists. Prevention of motion sickness | Scopolamine |
| Quaternary ammonium muscarinic antagonists. used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma | Ipatropium |
| Tertiary amine muscarinic antagonists. Used as mydriatic for fundoscopy. Produces mydriasis with cycloplegia | Tropicamide |
| Causes ganglion blockade by prolonged depolarization. | Nicotine |
| Ganglion blockade by antagonism of nicotinic receptors. | Hexamethonium |
| Non-depolarizing neuromuscular blocker that is a competitive antagonist. used as a adjuvant drug in anaesthesia during surgery to relax skeletal muscle. | Tubocurarine |
| Used for Rapid endotracheal intubation & ECT. Depolarizing neuro m. blocker that binds to the nicotinic receptor and depolarizes the junction. Persists in the synaptic cleft, stimulating the receptor: receptor desensitizes. leads to flaccid paralysis. | Succinylcholine |
Created by:
Quintin1
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