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Exam 2 drugs

The key function of Botulinum Toxin Prevents release of Acetylcholine
Botulinum Toxin's mechanism of action Inhibits release of Acetylcholine by degrading synaptobrevin (SNARE), which prevents vesicle fusion / exocytosis
Used to obtain miosis after delivery of the lens in cataract surgery and other procedures where rapid miosis is required Acetylcholine
Muscarinic and nicotinic agonist Acetylcholine
Muscarinic agonist for postoperative urinary retention. Atony of the urinary bladder Bethanechol
Muscarinic agonist used for diagnosis of bronchial airway hyperreactivity in subjects who do not have clinically apparent asthma. Methacholine
Partial muscarinic agonist for Glaucoma and treatment of dry mouth due to radiotherapy for cancer of head and neck Pilocarpine
Agonist at nicotinic receptors depolarizes autonomic ganglia, resulting first in stimulation and then in paralysis. Nicotine
Ganglionic stimulation by depolarization. The response resembles simultaneous discharge of both parasympathetic and sympathetic nervous systems Nicotine Low dose
ganglionic blockade and neuromuscular blockade Nicotine High dose
Anti-Cholinesterase that Does Not enter CNS. used for the diagnosis of myasthenia gravis: leads to rapid increase in muscle strength. Also used to reverse the neuromuscular block produced by non-depolarizing muscular blockers. Edrophonium
Anti-Cholinesterase that Can enter and stimulate CNS. Used for the treatment of overdoses of anticholinergic drugs. Physostigmine
Anti-Cholinesterase that Does Not enter CNS. used for Urinary retention. Reversal of effects of non-depolarizing neuromuscular blockers after surgery. Treatment of myasthenia gravis Neostigmine
Anticholinesterase that Does Not enter CNS. used solely for the treatment of myasthenia gravis, Pyridostigmine
Irreversible Anticholinesterase. irreversibly bind to active portions of AChE to form an extremely stable complex, which prevents ACh breakdown. causes muscle paralysis and death (Insecticide) Malathion
Organophosphate. Among the most potent synthetic toxic agents known. (nerve agent) Sarin
muscarinic antagonist Reversible competitive antagonist at muscarinic receptors. Tertiary amine: both central and peripheral muscarinic blocker. Atropine
M3 blockade for eye, GI, urinary system, secretions, and atrial M2 blockade for CV system. Antidote for cholinergic agonists. blocks respiratory tract secretions prior to surgery Atropine
Muscarinic receptor antagonists. Prevention of motion sickness Scopolamine
Quaternary ammonium muscarinic antagonists. used in the treatment of chronic obstructive pulmonary disease (COPD) and asthma Ipatropium
Tertiary amine muscarinic antagonists. Used as mydriatic for fundoscopy. Produces mydriasis with cycloplegia Tropicamide
Causes ganglion blockade by prolonged depolarization. Nicotine
Ganglion blockade by antagonism of nicotinic receptors. Hexamethonium
Non-depolarizing neuromuscular blocker that is a competitive antagonist. used as a adjuvant drug in anaesthesia during surgery to relax skeletal muscle. Tubocurarine
Used for Rapid endotracheal intubation & ECT. Depolarizing neuro m. blocker that binds to the nicotinic receptor and depolarizes the junction. Persists in the synaptic cleft, stimulating the receptor: receptor desensitizes. leads to flaccid paralysis. Succinylcholine
Created by: Quintin1



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