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m2018-drug-MOA

thru Neuro 2

drug MOA
lithium carbonate Eskalith® lithium alters sodium transport in nerve and muscle cells and effects a shift toward intraneuronal metabolism of catecholamines
alprazolam Xanax® (Schedule IV) mostly CNS by stimulating GABA receptor complex
amitriptyline Elavil® TCA (Tricyclic Antidepressant) prolong action of norepinephrine, dopamine, and seratonin by blocking reuptake
amphetamine and dextroamphetamine sulfate Adderall® Schedule II stimulates CNS activity; blocks reuptake and increases release of norepinephrine and dopamine in extraneuronal space (sympathomimetic)
baclofen Lioresal® centrally acting muscle relaxer
betaxolol Betoptic beta-blocker
bupropion Wellbutrin®/Zyban® Weak inhibitor of reuptake of norepinephrine and dopamine
buspirone BuSpar® partial dopamine and seratonin agonist
carbamazepine Tegretol® reduces post-tetanic potentiation, decreasing seizure spread; exact mechanism of action in trigeminal neuralgia or bipolar disorder unknown
carbidopa/ levodopa Sinemet® inhibits peripheral dopamine decarboxylation; crosses blood-brain barrier and serves as dopamine precursor
chlorpromazine Thorazine® principal pharmacological actions are psychotropic. It also exerts sedative and antiemetic activity
diazepam Valium® (Schedule IV) mostly CNS by stimulating GABA receptor complex
donepezil Aricept ODT® reversibly binds to and inactivates acetylcholinesterase (cholinesterase inhibitor)
echothiophate Phospholine Iodide cholinesterase inhibitor
fentanyl Sublimaze® Schedule II binds to various opioid receptors, producing analgesia and sedation (opioid agonist)
fluoxetine Prozac® SSRI (Selective Seratonin Reuptake Inhibitor)
haloperidol Haldol® Unknown
Interferon beta 1b Betaseron® binds to type 1 interferon receptors and activates tyrosine kinase, producing antiviral, antiproliferative, and immunomodulatory effects
Interferon beta-1a Avonex® binds to type 1 interferon receptors and activates tyrosine kinase, producing antiviral, antiproliferative, and immunomodulatory effects
lidocaine Xylocaine® inhibits Na ion channels, stabilizing neuronal cell membranes and inhibiting nerve impulse initiation and conduction (amide local anesthetic)
memantine Namenda® binds N-methyl-D-aspartate receptors, may slow Ca++ influx and nerve damage (NMDA receptor antagonist)
methylphenidate Ritalin® Schedule II stimulates CNS activity; blocks reuptake and increases release of norepinephrine and dopamine in extraneuronal space (sympathomimetic)
midazolam Versed® Schedule IV binds to benzodiazepine receptors; enhances GABA effects
modafinil Provigil® Schedule II binds to dopamine transporter, inhibiting dopamine reuptake
phenelzine Nardil® MAOi (MonoAmine Oxidase Inhibitor), monoamine oxidase enzyme widely distributed throughout body-lots of side effects, going from Nardil to Prozac wait 14 days, going from Prozac to Nardil, wait 5 weeks
phenytoin Dilantin® modulates neuronal voltage-dependent sodium and calcium channels
pilocarpine Pilocar cholinergic agonist
pramipexole Mirapex® stimulates dopamine receptors (dopamine agonist)
risperidone Risperdal® dopamine Type 2 (D2) and serotonin Type 2 (5HT2) receptor antagonism
selegiline Eldepryl® selectively inhibits MAO type B, increasing extracellular dopamine in the striatum
sodium thiopental Pentothal®Schedule II alters sensory cortex, cerebellar, and motor activities; produces sedation, hypnosis, and anesthesia (barbiturate)
sumatriptan Imitrex® activates vascular serotonin 5-HT1 receptors, producing vasoconstriction (selective serotonin agonist)
temazepam Restoril® Schedule IV binds to benzodiazepine receptors; enhances GABA effects
valproic acid Depakote® increases GABA effects, may inhibit glutamate/NMDA receptor-mediated neuronal excitation
venlafaxine Effexor® SNRI (Seratonin Norepinephrine Reuptake Inhibitor)
zolpidem Ambien® Schedule IV interacts w/ GABA-benzodiazepine receptor complexes
Created by: mchugh100
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