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NCLEX PHARM
CHAPTER 6
| Question | Answer |
|---|---|
| Which response would the nurse anticipate when giving two drugs that have a potentiative effect, such as meperidine and Phenergan? | Increased pain relief |
| The nurse is preparing a discharge teaching plan to a patient prescribed phenobarbital and oral contraceptives which are known to induce CYP isoenzymes. What patient teaching should the nurse include in the discharge plan? | Plan to use another form of birth control while taking phenobarbital.” |
| The drug the nurse is about to give induces P-glycoprotein (PGP). Which outcome should the nurse expect when this drug is given with other drugs? | Reduced absorption of other drugs Drugs that induce PGP can cause reduced absorption of other drugs, which would reduce their levels. A PGP inducer would not increase the side effects of other drugs and could increase elimination of other drugs. |
| The nurse is concerned with minimizing adverse drug-drug interactions for the patient. Which drug characteristic could result in the most serious consequences from a drug-drug interaction? | Low therapeutic range Interactions are especially important with drugs that have a narrow therapeutic range, because an interaction that produces a modest increase in drug levels can cause toxicity. |
| The nurse is teaching a patient prescribed felodipine [Plendil] for the treatment of hypertension. Which statement is the most appropriate for the nurse to include in the teaching session? | “Avoid grapefruit juice while you are taking this medication.” Grapefruit juice can raise levels of felodipine by as much as 406% because of the effect grapefruit juice has on the CYP3A4 isoenzyme. |
| Before administrating the dosage of a prescribed medication, the nurse observes precipitation formation of the intravenous (IV) solution. What is the priority nursing action? | Discard the IV solution. If a precipitate appears in the IV solution, that solution should be discharged. |
| The nurse reviews all of the patient’s prescriptions. Which prescribed medications may cause a detrimental potentiative drug interaction? | Aspirin and warfarin Aspirin and warfarin both suppress clotting. As a result, if aspirin and warfarin are taken concurrently, the risk of bleeding is significantly increased. |
Created by:
Bich Bui
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