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Pharmacy Tech Ch. 10

PT Ch. 10 & 11 Final

Agonists drugs that activate receptors to accelerate or slow normal cellular function.
onset of action the time MEC is reached and the response occurs.
Absorption the transfer of drug into the blood from an administered drug product.
metabolism The body's process of transforming drugs
kidneys filter the blood and remove waste materials from it
FDA requires drug manufacturers to perform bioequivalency studies on their products before they are approved for marketing
bioavailability The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs
bioequvalent drug products Drug products that contain identical amounts of the same active ingredients in the same dosage form
site of action The location where an administered drug produces an effect
passive diffusion The movement of drugs from an area of higher concentration to lower concentration
gastric emptying time The time a drug will stay in the stomach before it is emptied into the small intestine
protein binding The attachment of a drug molecule to a plasma or tissue protein, effectively making the drug inactive, but also keeping it within the body
enzyme A complex protein that causes chemical reactions in other substances
pharmaceutical alternative Drug products that contain the same active ingredients, but not necessarily in the same amount or dosage form
enzyme induction The increase in enzyme activity that results in greater metabolism of drugs
liver Enzyme inhibition typically occurs
intravenous route of administration does not have an absorption step
Receptors located on the surfaces of cell membranes and inside cells
Antagonists bind to cell receptors but do not activate them
pharmacogenetics The study of the hereditary basis of individual differences
hematological effects Anticoagulants can cause excessive bleeding
Inhibition when one drug blocks the activity of metabolic enzymes in the liver
Synergism when two drugs with different sites or mechanisms of action produce greater effects when taken together than when taken alone
Additive effects when two drugs with similar pharmacological actions are taken and the effect is equal to that of each drug taken alone
Carcinogenicity the ability of a substance to cause cancer
Hepatotoxicity toxic to the liver
site of action The place where a drug causes an effect to occur
small intestine Most drugs given orally are absorbed into the blood from the
K Spinach and other green vegetables contain vitamin ___ that inhibits the action of oral anticoagulants.
Intravenous route of administration does not have an absorption step
Bioavailability Rate and extent the drug is available to the site of action
Bioavailabilities Bioequivalency is determined by comparing the two products
Enterohepatic cycling involves the transfer of drugs and their metabolites from the liver into the intestines
After all receptors are occupied by a drug its effect can not still be increased by increasing the dose.
The number or sensitivity of receptors is affected by prolonged drug use
Most orally administered drugs are not absorbed from the stomach
Protein binding can result in the gradual release of a drug into the bloodstream
Most drugs and metabolites are excreted by the liver
Some anticancer drugs are considered carcinogenic.
criteria should not be used to determine drug dosages for infants age alone
In determining Kidney function, the creatinine clearance is used this measures the amount of blood cleared by the kidneys in ml/min
Created by: ksnow5



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