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Pharmacy Tech Ch. 10
PT Ch. 10 & 11 Final
Term | Definition |
---|---|
Agonists | drugs that activate receptors to accelerate or slow normal cellular function. |
onset of action | the time MEC is reached and the response occurs. |
Absorption | the transfer of drug into the blood from an administered drug product. |
metabolism | The body's process of transforming drugs |
kidneys | filter the blood and remove waste materials from it |
FDA | requires drug manufacturers to perform bioequivalency studies on their products before they are approved for marketing |
bioavailability | The relative amount of an administered dose that reaches the general circulation and the rate at which this occurs |
bioequvalent drug products | Drug products that contain identical amounts of the same active ingredients in the same dosage form |
site of action | The location where an administered drug produces an effect |
passive diffusion | The movement of drugs from an area of higher concentration to lower concentration |
gastric emptying time | The time a drug will stay in the stomach before it is emptied into the small intestine |
protein binding | The attachment of a drug molecule to a plasma or tissue protein, effectively making the drug inactive, but also keeping it within the body |
enzyme | A complex protein that causes chemical reactions in other substances |
pharmaceutical alternative | Drug products that contain the same active ingredients, but not necessarily in the same amount or dosage form |
enzyme induction | The increase in enzyme activity that results in greater metabolism of drugs |
liver | Enzyme inhibition typically occurs |
intravenous | route of administration does not have an absorption step |
Receptors | located on the surfaces of cell membranes and inside cells |
Antagonists | bind to cell receptors but do not activate them |
pharmacogenetics | The study of the hereditary basis of individual differences |
hematological effects | Anticoagulants can cause excessive bleeding |
Inhibition | when one drug blocks the activity of metabolic enzymes in the liver |
Synergism | when two drugs with different sites or mechanisms of action produce greater effects when taken together than when taken alone |
Additive effects | when two drugs with similar pharmacological actions are taken and the effect is equal to that of each drug taken alone |
Carcinogenicity | the ability of a substance to cause cancer |
Hepatotoxicity | toxic to the liver |
site of action | The place where a drug causes an effect to occur |
small intestine | Most drugs given orally are absorbed into the blood from the |
K | Spinach and other green vegetables contain vitamin ___ that inhibits the action of oral anticoagulants. |
Intravenous | route of administration does not have an absorption step |
Bioavailability | Rate and extent the drug is available to the site of action |
Bioavailabilities | Bioequivalency is determined by comparing the two products |
Enterohepatic cycling involves the transfer of drugs and their metabolites from the liver into the | intestines |
After all receptors are occupied by a drug | its effect can not still be increased by increasing the dose. |
The number or sensitivity of receptors | is affected by prolonged drug use |
Most orally administered drugs | are not absorbed from the stomach |
Protein binding can result in | the gradual release of a drug into the bloodstream |
Most drugs and metabolites are excreted by | the liver |
Some anticancer drugs are considered | carcinogenic. |
criteria should not be used to determine drug dosages for infants | age alone |
In determining Kidney function, the creatinine clearance is used this measures | the amount of blood cleared by the kidneys in ml/min |