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Antiepileptics

QuestionAnswer
Carbamazepine Anti-epileptic Drug / Binds fast inactivated Na+ channels extending the refractory period also voltage gated Ca2+/ Particularly effective for partial and secondary generalized seizures / Can make absence worse / Heart block
Lacosamide Anti-epileptic Drug / Binds fast inactivated Na+ channels extending the refractory period also voltage gated Ca2+/ Particularly effective for partial and secondary generalized seizures / Can make absence worse / Heart block
Diazepam Benzodiazepines / Positive allosteric modulator at GABAA receptor / Used in status epilepticus, acute anxiety, insomnia, muscle relax, alcohol withdrawl / Sedation, respiratory depression / Not first line
Lorazepam Benzodiazepines / Positive allosteric modulator at GABAA receptor / Used in status epilepticus, acute anxiety, insomnia, muscle relax, alcohol withdrawl / Sedation, respiratory depression / Not first line
Clonazepam Benzodiazepines / Positive allosteric modulator at GABAA receptor / Used in status epilepticus, acute anxiety, insomnia, muscle relax, alcohol withdrawl / Sedation, respiratory depression / Not first line
Phenobarbital Anti-epileptic Drug / Positive allosteric modulator at GABAA receptor that enhances duration of opening, high dose can act as a direct GABA agonist, blocks voltage-gated Ca / Used since 1912, effective with muliple epilepsy types but not absence
Tiagabine Anti-epileptic Drug / Inhibits the reuptake of GABA / Used for localization related epilepsies / Adjunctive therapy / Tremor dizziness, nervousness, difficulty concentrating, somnolence
Ethosuximide Anti-epileptic Drug / Blocks T-type calcium channels / Indicated for in absence epilepsy / Nausea, hiccups, anorexia, rash, Lupus syndrome / Sucks to have silent seizures
Gabapentin Anti-epileptic Drug / High-voltage-activated Ca2+ channel inhibitors thus decreasing transmitter release / Indicated for localizatoin-related epilepsies, post-herpetic neuralgia. / Mild nausea, somnolence and lightheadedness
Pregabalin Anti-epileptic Drug / High-voltage-activated Ca2+ channel inhibitors thus decreasing transmitter release / Indicated for localizatoin-related epilepsies, post-herpetic neuralgia, diabetic neuropathy pain. / Mild nausea, somnolence and lightheadedness
Levetiracetam Anti-epileptic Drug / Inhibits calcium channels and interacts with a unique synaptic vesicle protein / Indicated for localization-related and generalized epilepsies / Somnolence and lightheadedness / Really safe
Lamotrigine Anti-epileptic Drug / Stabilizes voltage-gated sodium channels in the inactivated state, inhibits glutamate release, t-type calcium currents / Used alone and in combo with other drugs for multiple types of epilepsy / Severe and life-threatening rash
Topiramate Anti-epileptic Drug / Direct potentiating actions on the GABA receptor at a unique site, inactivates voltage-gated sodium channels, prevents calcium influx / Treatment for localization-related epilepsies and generalized epilepsies, prevent migraines
Zonisamide Anti-epileptic Drug / Direct potentiating actions on the GABA receptor at a unique site, inactivates voltage-gated sodium channels, prevents calcium influx / Treatment for localization-related epilepsies and generalized epilepsies, prevent migraines
Valproate Anti-epileptic Drug / Blocks voltage-gated sodium channels in a unique manner, suppress calcium influx through t-type calcium channels / Indicated absence epilepsy, generalize epilepsy, localization-related epilepsy / Weight gain, tremor, liver fail
Phenytoin Anti-epileptic Drug / Binds fast inactivated Na channels extending the refractory period also voltage gated Ca/ Particularly effective for partial and secondary generalized seizures / Can make absence worse / Heart block, arrhythmias / Weird kinetics
Created by: carchase
 

 



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