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Sleep Drugs

Drugs used for sleep disorders

QuestionAnswer
Triazolam Benzodiazepine / Positive allosteric modulator at GABA receptor acting to enhance frequency of channel opening in response to GABA resulting in enhanced membrane hyperpolarization / Used for anxiety disorders, insomnia, epilepsy, sedation, muscle relax
Zaleplon Non-benzodiazepines / Allosteric agonist at GABA-a receptor acting to enhance frequency of channel opening in response to GABA / Mainly used for insomnia
Zolpidem Non-benzodiazepines / Allosteric agonist at GABA-a receptor acting to enhance frequency of channel opening in response to GABA / Mainly used for insomnia / Special alert regarding complex sleep behaviors, lower dosage for women because they metabo slow
Eszopiclone Non-benzodiazepines / Allosteric agonist at GABA-a receptor acting to enhance frequency of channel opening in response to GABA / Mainly used for insomnia
Doxepin Low dose is selective histamine antagonist, higher dose is a tricyclic antidepressant and anticholin ergic effect. / At low doses for insomnia / BBW: potential for increased suicidal ideations. Do not use in patients who have taken MAOs.
Diphenhydramine Benedryl / Antihistamine with some antimuscarinic effects / NOT RECOMMENDED for long term use.
Suvorexant Orexin receptor antagonist. (Orexin receptors in hypothalamus) / Used for insomnia / Not CNS depressant, does not seem to produce rebound insomnia.
Trazodone SSRI / Off-label use for insomnia / Most widely prescribed sleep aid in US.
Ramelteon Agonist at melatonin receptors and thus modulates circadian rhythms involved in sleep wake cycle / No direct effect on GABA receptors / Not really any issues
Created by: deleted user
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