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Dabigatran (oral)
ANTICOAGULANTS (Direct thrombin inhibitors)
Term | Definition |
---|---|
Indication | VTE Non-valvular AF + high risk of stroke /systemic embolism |
Contraindication | GI hemorrhage within previous 12 months Prosthetic heart valve MI |
Adverse effects | GI bleeding Gastritis ( inflammation (irritation) of the stomach lining) Dysepsia (discomfort or pain in the upper abdomen) |
Mode of action | For direct thrombin inhibitors: inhibit both free and fibrin-bound thrombin, preventing fibrinogen converting to fibrin, prevent thrombus formation |
Route/dose | Oral 10 days after THR VTE+ after surgery:110mg after 1-4hr of the surgery, then 220mg once daily AF, acute VTE: paren anticoagulant for 5 days before dabigatran, adults: elder= 150:110 x2 daily |
How to remember | Đã bị gạt rồi |
Comments | Antidote: idarucizumab |