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Dabigatran (oral)

ANTICOAGULANTS (Direct thrombin inhibitors)

Indication VTE Non-valvular AF + high risk of stroke /systemic embolism
Contraindication GI hemorrhage within previous 12 months Prosthetic heart valve MI
Adverse effects GI bleeding Gastritis ( inflammation (irritation) of the stomach lining) Dysepsia (discomfort or pain in the upper abdomen)
Mode of action For direct thrombin inhibitors: inhibit both free and fibrin-bound thrombin, preventing fibrinogen converting to fibrin, prevent thrombus formation
Route/dose Oral 10 days after THR VTE+ after surgery:110mg after 1-4hr of the surgery, then 220mg once daily AF, acute VTE: paren anticoagulant for 5 days before dabigatran, adults: elder= 150:110 x2 daily
How to remember Đã bị gạt rồi
Comments Antidote: idarucizumab
Created by: bttr



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