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Eye Drugs

Drugs for treating the eyes

QuestionAnswerSide Effects
bevacizumab (1st gen) monoclonal antibody / Binds all forms of VEGF-A / Inhibit angiogenesis by inhibiting vascular endothelial growth factor (VEGF) binding to VEGF receptors / Contraindicated for ocular infections / Used for diabetic optic neuropathy Some common side effects • Conjunctival hemorrhage • Vitreous floaters • Eye infection that may include eye pain, light sensitivity, vision changes. • Increased intraocular pressure • Cataract • Vitreous detachment
ranibizumab (2nd gen) antibody fragment / Binds all forms of VEGF-A better / Inhibit angiogenesis by inhibiting vascular endothelial growth factor (VEGF) binding to VEGF receptors / Contraindicated for ocular infections / Used for diabetic optic neuropathy Some common side effects • Conjunctival hemorrhage • Vitreous floaters • Eye infection that may include eye pain, light sensitivity, vision changes. • Increased intraocular pressure • Cataract • Vitreous detachment
aflibercept (3rd gen) fusion protein / Binds VEGF-A, VEGF-B, and PGIF tightest / Inhibit angiogenesis by inhibiting vascular endothelial growth factor (VEGF) binding to VEGF receptors / Contraindicated for ocular infections / Used for diabetic optic neuropathy Some common side effects • Conjunctival hemorrhage • Vitreous floaters • Eye infection that may include eye pain, light sensitivity, vision changes. • Increased intraocular pressure • Cataract • Vitreous detachment
timolol Beta adrenergic blocker / Agents that suppress aqueous inflow Ocular irritation and dry eyes. Contraindicated in patients with bradycardia, heart block, heart failure, asthma, or obstructive airway disease.
brimonidine Alpha-2 adrenergic agonist / Agents that suppress aqueous inflow and increase aqueous outflow Red eye and ocular irritation. CNS effects and respiratory arrest in young children (brimonidine). Caution in patients with cerebral or coronary insufficiency, Raynaud phenomenon, postural hypotension, hepatic or renal impairment.
dorzolamide Carbonic anhydrase inhibitors (topical) / Agents that suppress aqueous inflow Oral form can cause transient myopia, nausea, diarrhea, loss of appetite and taste, parasthesiae, lassitude, renal stones, and hematological problems. Topical forms much less likely to cause systemic side effects but can cause local irritation and redness
brinzolamide Carbonic anhydrase inhibitors (topical) / Agents that suppress aqueous inflow Oral form can cause transient myopia, nausea, diarrhea, loss of appetite and taste, parasthesiae, lassitude, renal stones, and hematological problems. Topical forms much less likely to cause systemic side effects but can cause local irritation and redness
bimatoprost Prostaglandin analogues / Agents that increase aqueous outflow Brown discoloration of iris, lengthening and darkening of eyelashes, ocular irritation and redness, macular edema or iritis in susceptible individuals
latanoprost Prostaglandin analogues / Agents that increase aqueous outflow Brown discoloration of iris, lengthening and darkening of eyelashes, ocular irritation and redness, macular edema or iritis in susceptible individuals
pilocarpine Cholinergic agonists / Agents that increase aqueous outflow Ciliary spasm leading to headaches especially in younger patients, myopia, dim vision (small pupil). Cataracts and irislens adhesions in long term.
Created by: carchase