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Heparin
ANTICOAGULANT (Heparins/Parenteral)
Term | Definition |
---|---|
Indication | Peripheral arterial occlusion VTE , ACS, DIC |
Contraindication | Thrombocytopenia (with great care), risk of bleeding, severe hepatic/renal impairment, History of heparin-induced thrombocytopenia Hypersensitivity |
Adverse effects | Bleeding, pain at the injection site, bruising, hyperkalemia, mild reversible thrombocytopenia |
Dose/ Route | SC, IV No MI bc of risk of hematoma |
Mode of action | inactivate clotting factors IIa (thrombin) and Xa by binding to antithrombin III, |