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Drug Class_MOA
Drug Class and Corresponding Mech of Action
| Drug class | Mechanism of action |
|---|---|
| antibiotics/ cephalosporins | inhibits cell wall synthesis by acylation of transpeptidase |
| Narcotic Anagelsic | interacts primarily w. opiate receptors by producing anagelsia |
| Antiepileptic | phenytoin increases the extrusion of Na ions from neurons & cardiac myoctes, this produces a stabilization of the excitable membrane to repetitive stimuli |
| CV-Beta Blocker | beta adrenergic blocking results in reduction in cardiac output, reduction in exercise &/ isoproterenol-induced tachycardia & reduces reflex orthostatic tachycardia |
| Anti-coagulants | Warfarin antagonizes Vit K resulting in a decreased hepatic synthesis of the vit k dependent clotting factors (II, VII, IX, & X) |
| CV-Angiotensin II Antagonist | blocks the vasoconstrictor and aldolsterone secreting effects of Angiotensin II by binding by selectively blocking the BINDING of angiotensin II to ATI receptors in many tissues |
| Antidepressant | inhibits neuronal serotonin uptake and norepinphrine reuptake |
| Antihistamines | antagonize HI (histamine) receptors in peripheral tissues |
| Agent for Glaucoma | inhibits carbonic anhydrase II in the ciliary processes of the eye by decreasimg aq. humor secretion by slowing the formation of bicarbonate ions with subsequent reduction in Na & fluid transport |
| Antihyperlipidimic | competive inhibitor of HMG CoA reductase, reduces total cholesterol, LDL-C apo B and triglycerides & produces variable increases in HDL and apolipoprotein |
| Clindamycin | binds to 50S subunit of bacterial ribosomes & suppress protein synthesis |
| Diuretic | inhibits the reabsorption of Na in exchange for K at the distal renal tubule, Hydrochlorothaizide also inhbits reabsorption of Na & Cl at the distal renal tubule |
| Diuretic Loop | inhibits Na+/K+/2Cl- in the ascending portion of the loop of henle, increases the urinary excretion of Na, Cl & water but does not signfic. alter glomerular filt. rate, renal plasma flow or acid-base balance |
| Hormone/Estrogen | promote growth and development of the vagina, uterus and fallopian tubes & enlargement of the breasts |
| Ovulatory/ Fertility agent | Promotes secretion of LH, FSH and gonadotropins resulting in increased gametogenesis & steroidogenesis in the ovaries |
| Hormone/Progestin | inhibits the secretion of gonadotropins wc in turn prevents follicular maturation & ovulation & results in endometrial thining |
| GI- Anticholinergic | Inhbits the muscarinic action of acetycholine on smooth muscle. |
| Acne Agent | binds to specific retinoic acid nuclear receptors where it modulates cellular differentiation, keratinization and inflammation processes |
| CNS stimulant | thought to block the uptake of norepinephrine and dopamine into the presynaptic neuron and increase release of these monoamines into the extraneuronal space |
Created by:
jmonkam
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