Save
Upgrade to remove ads
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Immunosuppressants

DrugFamilyMechanismSide Effects
Prednisone - sone / Glucocorticoids / Antagonizes insulin action & promotes gluconeogenesis / Increases muscle catabolism / Augments growth hormone action on lipolysis / Decreases inflammatory response / Reduces cytokine release inhibit NFkB. Binds intracellularly to a Type II glucocorticoid receptor and is transported into the nucleus. The complex binds to a so-called response element (DNA sequence) which up-regulates or down-regulates the transcription / expression of genes. Increased susceptibility to infections / Cushing's Syndrome (moon face) / Myopathy
Cyclosporine A Calcineurin inhibitors / Inhibitors of T-cell mediated immunity Inhibition of T-lymphocyte activation, thus reduced IL-2 production. / Extensively metabolized by CYP450 3A / Interacts with drugs that also use CYP450 3A. Including Grapefruit juice TDM needed because of high potential for nephrotoxicity
Tacrolimus Calcineurin inhibitors / Tacrolimus more potent than cyclosporine A Inhibition of T-lymphocyte activation, thus reduced IL-2 production. / Extensively metabolized by CYP450 3A / Interacts with drugs that also use CYP450 3A. Including Grapefruit juice TDM needed because of high potential for nephrotoxicity
Sirolimus Antiproliferatives / Anti-metabolites / Lymphocyte signaling inhibitor / Prophylaxis in organ transplantation Blocks IL-2 receptor signaling and arrests cell division by blocking kinase mTOR. Prevents IL-2 mediated signal transduction to cell nucleus. / Extensively metabolized by CYP450 3A not nephrotoxic / lung toxicity (interstitial pneumonitis)
Azathioprine Antiproliferatives / Anti-metabolites / Purine antimetabolite that inhibits proliferation of T cells and B cells. rapidly, non enzymatically cleaved into 6-mercaptopurine (6-MP) which acts as a purine analogue (adenine & guanine) causing inhibition of DNA synthesis (false nucleotide incorporation) and thus inhibition of proliferation of T cells and B cells. myelosuppression (bone marrow suppression) causing anemia and/or increased susceptibility to infection / nausea, vomiting
Methotrexate Antiproliferatives / Anti-metabolites / Competitive analog of folate Inhibits the metabolism of folate by inhibiting dihydrofolate reductase, blocking purine biosynthesis and leading to accumulation of adenosine and inhibition of T cell activation. Hepatotoxicty, anemia, azotemia / Penicillin may increase elimination.
Mycophenolic Acid Antiproliferatives / Anti-metabolites / Inhibits the de novo synthesis of lymphocyte purine nucleotides prevents production of guanosine nucleotides required for DNA synthesis thus, it prevents the proliferation of T-cells, lymphocytes, and the formation of antibodies from B-cells; it also may inhibit recruitment of leukocytes to inflammatory sites high blood sugars, increased blood cholesterol levels
Muromonab-CD3 (OKT3) Biologics / Biological modifiers / Mouse monoclonal antibody against the human CD3 receptor, a membrane protein on the surface of T cells Prevents T cell activation and proliferation by binding the T cell receptor complex present on all differentiated T cells (causing apoptosis) Cytokine release syndrome / Repeated administration can cause tachyphylaxis / Not approved for prophylaxis
Anti-thymocyte Globulin (ATG) Biologics / Biological modifiers / polyclonal antibodies (derived from rabbit or horse) against human T-cells (CDs) cytokine release syndrome
Daclizumab Biologics / Biological modifiers / humanized anti-CD25 (anti-IL-2α) mouse monoclonal antibody bind to IL-2α receptor on activated T-cells and block IL-2 mediated T-cell activation / expansion of activated lymphocytes and shortening their survival
Basiliximab Biologics / Biological modifiers / humanized anti-CD25 (anti-IL-2α) mouse monoclonal antibody bind to IL-2α receptor on activated T-cells and block IL-2 mediated T-cell activation / expansion of activated lymphocytes and shortening their survival
Created by: deleted user
Popular Pharmacology sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards