click below
click below
Normal Size Small Size show me how
Autonomic Drugs
Drug | Category | Action | Use | Notes |
---|---|---|---|---|
Acetylcholine | Direct cholinergic agonist | Ester of choline | ||
Bethanechol | Direct cholinergic agonist Muscarinic | Ester of choline | ||
Muscarine | Direct cholinergic agonist Muscarinic | Alkaloid | ||
Nicotine | Direct cholinergic agonist | In excess: muscarinic except bradycardia | Alkaloid | |
Pilocarpine | Direct cholinergic agonist Muscarinic | Glaucoma treatment | Alkaloid | |
Physostigmine | Carbamate Reversible Indirect acting cholinomimetric | Binds to AChE - intermediate time Same as ACh | ||
Echothiophate | Organophosphate Irreversible Indirect acting cholinomimetric | Binds to AChE - long time Same as ACh | Pesticides, nerve gas | In excess: muscarinic, then CNSconvulsions, coma, resp dep, peripheral N, paralysis |
Atropine | Cholinergic antagonist Antimuscarinic | |||
Trimethaphan | Cholinergic antagonist Antinicotinic (NN) | |||
D-turbocurarine | Cholinergic antagonist Anti nicotinic (NM) | |||
Epinephrine | Direct acting mixed sympathomimetic | Beta, alpha stimulation (mostly B-2) | ||
Norepinephrine | Direct acting mixed sympathomimetic | Beta, alpha stimulation | ||
Phenylephrine | Direct acting alpha-1 sympathomimetic | Increase alpha-1 stimulation | Baroresponse - bl vessels constrict, increase BP | |
Clonidine | Direct acting alpha-2 sympathomimetic | Increase alpha-2 stimulation | opiate drug withdrawal, hypertension, pain, ADHD, glaucoma, diarrhea etc | |
Dobutamine | Direct acting beta-1 sympathomimetic | Increase beta-1 | Baroresponse - increase HR, increase CO, increase BP | |
Isoproterenol | Direct acting beta sympathomimetic | |||
Albuterol | Direct acting beta-2 sympathomimetic | |||
Tyramine | Indirect acting sympathomimetic | increases NE release | ||
Amphetamine | Indirect acting sympathomimetic | Stimulates NE release | ||
Cocaine | Indirect acting sympathomimetic | Prevents NE reuptake | ||
Prazosin | Adrenergic antagonist alpha-1 blocker | Relax sphincters | BaroRc response - increase HR by beta-1 | |
Yohimbine | Adrenergic antagonist alpha-2 blocker | increase ACh release | ||
Metoprolol | Adrenergic antagonist Beta-1 blocker | BaroRc response - vasoconstriction via alpha-1 | ||
Propranolol | Adrenergic antagonist beta-1, 2 blocker | |||
Butoxamine | Adrenergic antagonist beta-2 blocker | bronchoconstriction, increase GIT motility (Sm muscle contraction) |