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Autonomic Drugs

DrugCategoryActionUseNotes
Acetylcholine Direct cholinergic agonist Ester of choline
Bethanechol Direct cholinergic agonist Muscarinic Ester of choline
Muscarine Direct cholinergic agonist Muscarinic Alkaloid
Nicotine Direct cholinergic agonist In excess: muscarinic except bradycardia Alkaloid
Pilocarpine Direct cholinergic agonist Muscarinic Glaucoma treatment Alkaloid
Physostigmine Carbamate Reversible Indirect acting cholinomimetric Binds to AChE - intermediate time Same as ACh
Echothiophate Organophosphate Irreversible Indirect acting cholinomimetric Binds to AChE - long time Same as ACh Pesticides, nerve gas In excess: muscarinic, then CNSconvulsions, coma, resp dep, peripheral N, paralysis
Atropine Cholinergic antagonist Antimuscarinic
Trimethaphan Cholinergic antagonist Antinicotinic (NN)
D-turbocurarine Cholinergic antagonist Anti nicotinic (NM)
Epinephrine Direct acting mixed sympathomimetic Beta, alpha stimulation (mostly B-2)
Norepinephrine Direct acting mixed sympathomimetic Beta, alpha stimulation
Phenylephrine Direct acting alpha-1 sympathomimetic Increase alpha-1 stimulation Baroresponse - bl vessels constrict, increase BP
Clonidine Direct acting alpha-2 sympathomimetic Increase alpha-2 stimulation opiate drug withdrawal, hypertension, pain, ADHD, glaucoma, diarrhea etc
Dobutamine Direct acting beta-1 sympathomimetic Increase beta-1 Baroresponse - increase HR, increase CO, increase BP
Isoproterenol Direct acting beta sympathomimetic
Albuterol Direct acting beta-2 sympathomimetic
Tyramine Indirect acting sympathomimetic increases NE release
Amphetamine Indirect acting sympathomimetic Stimulates NE release
Cocaine Indirect acting sympathomimetic Prevents NE reuptake
Prazosin Adrenergic antagonist alpha-1 blocker Relax sphincters BaroRc response - increase HR by beta-1
Yohimbine Adrenergic antagonist alpha-2 blocker increase ACh release
Metoprolol Adrenergic antagonist Beta-1 blocker BaroRc response - vasoconstriction via alpha-1
Propranolol Adrenergic antagonist beta-1, 2 blocker
Butoxamine Adrenergic antagonist beta-2 blocker bronchoconstriction, increase GIT motility (Sm muscle contraction)
Created by: Annya8