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Anti-VFPHI

Antivirals, Antifungals, Antiparisitics, Antihistimines, Antiinflammatory

DrugClass/Family
acyclovir -cyclovir / Antiviral / Inhibition of viral DNA synthesis / Herpes Simplex V, Varicella Zoster V, cytomegalovirus, Epstein-Barr virus / Renal Clearance / Nephrotoxicity, neurotoxicity / Interaction with zidovudine
ganciclovir -cyclovir / Antiviral / Inhibition of viral DNA synthesis / Herpes Simplex V, Varicella Zoster V, cytomegalovirus, Epstein-Barr virus / Renal Clearance / Nephrotoxicity, neurotoxicity / Interaction with zidovudine
foscarnet no root / Antiviral / Inhibition of viral DNA polymerase, RNA polymerase & HIV reverse transcriptase / HSV, VZV, cytomegalovirus, Epstein-Barr virus / NOT FIRST LINE / Renal Elimination / Nephrotoxicity /
amantadine -mantadine / Antiviral / Inhibition of viral uncoating / Influenza A/ NOT Commonly Used / Very common resistance / <5% have CNS toxicity / Interaction with antihistamines, anticholinergics, alcohol
oseltamivir -amivir / Antiviral / Neuraminidase Inhibitor / Inhibition of viral budding / Influenza A & B / MUST BE USED IMMEDIATELY / Resistance fairly common / CI distress, Pregnancy Category C / Interaction with live vaccines
zanamivir -amivir / Antiviral / Neuraminidase Inhibitor / Inhibition of viral budding / Influenza A & B / MUST BE USED IMMEDIATELY / Resistance fairly common / CI distress, Pregnancy Category C / Interaction with live vaccines
ribavirin no root / Antiviral / inhibition of IMPDH leads to depletion of GTP levels, can also inhibit viral RNA polymerase / Hepatitis C / Interacts with zidovudine / Pregnancy category X / Anemia
zidovudine no root / Antiviral / Nucleoside Reverse Transcriptase Inhivitor (NRTI) (Thymidine homolog) / HIV / RARELY USED NOW because of frequent drug interactions / Granulocytopenia, metabolic lactic acidosis
nevirapine no root / Antiviral / Non-nucleoside Reverse Transcriptase Inhibitor / HIV / CYP P450s Clearance / rash, liver toxicity
indinavir no root / Antiviral / HIV-protease inhibitor / HIV / RARELY USED NOW / CYP P450s Clearance / Altered lipid metabolism & fat redistribution, nephrolithiasis
caspofungin -fungin / Antifungal / Cell wall synthesis by inhibiting 1,3-beta glucan synthase. Fungicidal / Invasive candidiasis, aspergillosis / Very well-tolerated / Hepatic clearance / IV infusion / Interaction with immunosuppressants
amphotericin B no root / Antifungal / Binds ergosterol in fungal membranes and forms a pore / Broad-spectrum for severe fungal infections / IV infusion / Renal clearance / Side effects are "amphoterrible"
terbinafine no root / Antifungal / inhibits ergosterol synthesis enzyme squalene epoxidase decreases mebmrane fluidity and integrity / dermatophytes
fluconazole -conazole / Antifungal / interfere with ergosterol synthesis inhibit lanosteral-14 alpha demethylase / superficial and systemic fungal infections / CSF distribution / Renal elimination
itraconazole -conazole / Antifungal / interfere with ergosterol synthesis inhibit lanosteral-14 alpha demethylase / superficial and systemic fungal infections / hepatotoxicity / NOT CSF / Metabolic clearance
flucytosine no root / Antifungal / inhibits DNA synthesis, converted to 5'fluorouracil (toxic) / systemic fungal infections (used with amphotericin B to treat cryptococcal meningitis / renal eliminated / CONTRAINDICATED during pregnancy
griseofulvin no root / Antifungal / binds microtubules, mitosis inhibitor / restricted to dermatophytes / must be used until injured tissue replaces itself
pentamidine no root / Antifungal / poorly understood mechanism, interacts with DNA, RNA, topoisomerase, and ubiquitin / Alternative treatment for pneumocystitis jiroveci pneumonia / nephrotoxiticy, cardiovascular, hypoglycemia / NO CNS penetration
trimethroprim (TMP) / sulfamethoxazole (SMX) no root / Antifungal & Antibacterial / folate antagonist / SMX inhibits dihydropteroate synthase (DHPS) / TMP inhibits dihydrofolate reductase (DHFR) /
metronidazole Antiparisitic / lots
chloroquine Antiparisitic / malaria
quinine/quinidine Antiparisitic / malaria
gluconate Antiparisitic / cutaneous or visceral leishmaniasis
atovaquone-proguanil Antiparisitic / Babesiosis
primaquine Antiparisitic / malaria
sulfadiazine/pyrimethamine Antiparisitic / malaria
sodium stibogluconate Antiparisitic / Visceral leishmaniasis
nifurtimox Antiparisitic / American trypanosomes/Chagas’ disease
suramin Antiparisitic / African sleeping sickness
melarsoprol Antiparisitic / African sleeping sickness
mebendazole Antiparisitic / whipworm
pyrantel pamoate Antiparisitic / hookworms
ivermectin Antiparisitic / threadworm
praziquantel Antiparisitic / Flatworms and cestodes
diphenhydramine Antihistamine / 1st Gen H1 receptor antagonist (sedation) / Widely distributed in body including CNS / Competitive Inhibitor / Used in allergic reactions, cold and flu, motion sickness, parkinson's
promethazine Antihistamine / 1st Gen H1 receptor antagonist (sedation) / Widely distributed in body including CNS / Competitive Inhibitor / Used in allergic reactions, cold and flu, motion sickness, parkinson's
dimenhydrinate Antihistamine / 1st Gen H1 receptor antagonist (sedation) / Widely distributed in body including CNS / Competitive Inhibitor / Used in allergic reactions, cold and flu, motion sickness, parkinson's
chlorpheniramine Antihistamine / 1st Gen H1 receptor antagonist (sedation) / Widely distributed in body including CNS / Competitive Inhibitor / Used in allergic reactions, cold and flu, motion sickness, parkinson's
cetirizine Antihistamine 2nd Gen H1 Receptor Antagonist / NOT distributed to CNS, more selective for peripheral H1 receptors / Inhibits H1 receptor / Used for allergic reactions
loratadine Antihistamine 2nd Gen H1 Receptor Antagonist / NOT distributed to CNS, more selective for peripheral H1 receptors / Inhibits H1 receptor / Used for allergic reactions
fexofenadine Antihistamine 3rd Gen H1 Receptor Antagonist / Increased efficacy & fewer adverse effects / Inhibits H1 receptor / Used for allergic reactions
acetylsalicylic acid Anti-inflammatory (NSAIDs) / Aspirin / Low doses have an anti-thrombotic effect / Intermediate doses as an analgesis, antipyretic, anti-inflammatory effects by inhibition of COX-1 & 2/ High doses as anti-inflammatory effects in rheumatic disorders
celecoxib Anti-inflammatory (NSAIDs) / Selective inhibition of COX-2 with minimal effect on COX-1 / GI side effects and Renal toxicity less than other NSAIDs. / No significant inhibition of platelet aggregation / Potential for MI or stroke / Pain, swell, infla
ibuprofen Anti-inflammatory (NSAIDs) / non-selective, reversible inhibition of COX-1 and COX-2 / lowest incidence of GI side ffects of all NSAIDs / Fever, mild to moderate pain, inflammation
naproxen Anti-inflammatory (NSAIDs) / non-selective, reversible inhibition of COX-1 and COX-2 / smallest overall cardiovascular risks of NSAIDs / Fever, mild to moderate pain, inflammation
Created by: carchase