Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
beta lactams
pharm of beta lactams
| Question | Answer |
|---|---|
| mechanisms of resistance to PCN | inactivation by Beta-lactamase, modification of target PBP's, impaired penetration of drug to target PBP's, presence of an efflux pump |
| carbapenems | indicated for infections caused by susceptible organisms that are resistant to toher drugs and for threatment of mixed aerobic and anaerobic; and enterobacoter infections |
| Vancomycin | active only against gram-positive bacteria ( but also flavobacterium) |
| Vancomycin | administered orally only for C. diff |
| Vancomycin | excreted by kidney, mainly used for spesis or endocarditis caused by MRSA |
| Monobactams | Aztreonam |
| Monobactams | relatively resistant to Beta lactamses |
| Monobactams | active against gram negative rods, no activit against gram positive or anaerobes |
| Monobactams | PCN-allergic patients tolerate without reaction |
| beta lactamase inhibitors | resemble beta lactame molecules--> clavulanic acid, sulbactam, tazobactam |
| 3rd generation cephalosporins | extended gam negative coverage, cross the blood brain barrier, active against beta lactamase producing hemophilus and neiseria, used as theray for sepsis of unkown cause |
| 4th generation cephalosporins | used for enterobacter |
| 2nd generation cephalosporins | better gram negative coverage including Klebsiella but less effective gram positive, oral agents active against beta lactamase producing H. influenza or Branhamella cattarrhalis and are used to treat sinusitis, otits, and lower respiratory infections |
| 1st gen. cephalosporins | gram positive cocci, especially pnueomococci, streptococci, and staphylococci |
| 1st gen. cephalosporins | excreted by the kidney, used for UTI, minor staph infection and cellulitis |
| cefazolin | penetrates tissues well and is the drug of choice for surgical prophylaxis |
| penicillins | greatest activity against gram positive and gram negative cocci, and non beta lactamase producing anaerobes |
| antistaphlococcal penicillins | resistant to staph beta lactamases active against staph and strep but not enterococci, anearobics, and gram negative cocci and rods |
| PCN | rapidly excreted by kindey, normal half life 30min, in renal failure half fife is 19 Hrs |
| Nafcillin | primarily excreted by biliary |
| oxacillin, dicloxacillin, cloxacillin | eliminated by both renal and biliary |
| Vanco | Drug used for MRSA |
| Vancomycin MOA | Blocks peptidoglycan synthesis |
| Type of resistance found with vancomycin | Point mutation |
| Penicillins active against penicillinase secreting bacteria | Methicillin, nafcillin, and dicloxacillin |
| Amoxicillin | Cheap wide spectrum antibiotic DOC of otitis media |
| Cephalosporins | Class of antibiotics that have 10% cross sensitivity with penicillins |
| Carbenicillin, piperacillin and ticarcillin | PCN active against pseudomonas |
| Antibiotic causing red-man syndrome, and prevention | Vancomycin, infusion at a slow rate and antihistamines |
Created by:
swohlers
Popular Pharmacology sets