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Pharm chapter 32

The stomach has 3 primary functions storing food until it can be processed in the lower GI tract: miking food with gastric secretions until it is a partially digested, semisolid mixture known as chyme: and slowly emptying the stomach at a rate that allows proper digestion and absorption
what secretory cells line portions of the stomach chief, parietal, and mucus cells
chief cells secrete pepsinogen, an inactive enzyme
Parietal cells secrete hydrochloric acid by way of a hydrogen ion pump, which activates pepsinogen to pepsin
normal pH of the stomach? 1 to 5, depending on the presence of food and medications
mucous cells secrete mucus, which coats the stomach wall and protects the stomach wall from damage by hydrochloric acid and pepsin
Lipases digest? Fat
Gastric Amalase digests? carbohydrates
Gastroesophageal reflux disease (GERD) is the reflux of gastric secretions, primarily pepsin and hydrochloric acid, up into the esophagus
Causes of GERD weakened lower esophageal sphincter, delayed gastric emptying, hiatal hernia, obesity, overeating, tight fitting clothing, and increased acid secretions
frequent bouts of GERD lead to inflammation, tissue erosion and ulcerations in the lower esophagus
Peptic ulcer disease (PUD) refers to several stomach disorders that result from an imbalance between acidic stomach contents and the body normal defense barrier causing ulcerations in the GI tract
Antacids lower the acidity of gastric secretions by buffering the hydrochloric acid, are commonly used for heartburn, excessive eating and drinking and PUD
Simethicone is a defaming agent that breaks up gas bubbles in the stomach, reducing stomach distention and heartburn.
the most effective antacid are combinations of aluminum hydroxide, magnesium oxide or hydroxide, and calcium carbonate
who should use low sodium antacids patients with edema, heart failure, hypertension, renal failure, pregnancy, or salt restricted diets
Created by: Aslaughter



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