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Allergic Rhinitis
Antihistamines
Brand | Generic | Mechanism | Notes |
---|---|---|---|
Benadryl | Diphenhydramine | First Generation Antihistamine | Sedation and anticholinergic |
Chlorpheniramine | Chlor- Trimeton | First Generation Antihistamine | Sedation and anticholinergic |
Dimetapp | Brompheneramine | First Generation Antihistamine | Sedation and anticholinergic |
Tavist | Clemastine | First Generation Antihistamine | Sedation and anticholinergic |
Zyrtec | Cetirizine | Second Generation Antihistamine | Mild sedation and anticholinergic |
Allegra | Fexofenadine | Second Generation Antihistamine | No Sedation/ anticholinergic |
Clarinex | Desloratadine | Second Generation Antihistamine | Mild Sedation / anticholinergic |
Claritin | Loratadine | Second Generation Antihistamine | Mild Sedation/ Anticholinergic Rapid effect < 1 hr for nasal and ocular symptoms |
Astelin, Astepro | Azelastine | Intranasal antihistamine | > 6 yoa AE: Drowsiness, Bitter taste Epistaxis, nasal discomfort |
Patanase | Olopatadine | Intranasal antihistamine | > 6 yoa AE: Bitter tase, drowsiness, epistaxis |
1st generation antihistamines | Avoid in: heavy machinery/ extensive driving/ pilots, pre-existing mental impairment, BPH, elevated Intraocular pressure | Limited treatment in Allergic Rhinitis | May produce performance impairment |
2nd Generation Antihistamines | Drug Interactions: CNS depressants, MAOI's, Phenytoin, Ketoconazole, Erythromycin, Cimetidine, St. Johns Wort | ||
Intranasal Antihistamines | equal or superior to 2nd generation PO antihistamines | Less effective than nasal steroids for nasal symptoms | |
Optivar | Azelastine | MastCell Stabilizer -Opth antihistamine | > 3 yoa Used for itching associated w/ allergic conjunctivitis wait at least 10 mins before inserting contacts |
Patanol, Pataday | Olopatadine | Mast Cell Stabilizer | > 3 yoa Wait at least 10 mins before inserting contacts |
Lastacaft | Alacftadine | Opth antihistamine | Wait at least 10 mins before inserting contacts |
Emadine | Emedastine | Opth antihistamine | > 3 yoa MastCell Stabilizer -Opth antihistamine |
Naphcon-A, Opcon-A, Visine- A | Nephazoline/ Pheniramine | Opth antihistamine | Can Cause Rebound |
Decongestants | Topical / systemic formulations | Vasoconstriction of andrenergic receptor in nasal mucosa | Reduce nasal congestion some rhinorrhea Minimal effect on sneezing, itching, or ocular symptoms |
Oral Decongestants | Use with caution in: Cardiovascular disease Hyperthyroidism Glaucoma Any Bladder/ neck obstruction DO NOT use within 14 days of MAOI's | ADE's: Nervousness, Insomnia, irritability, headache, palpitations, tachycardia, increased blood pressure, increase interocular pressure, aggravate urinary obstruction | Pseudophedrine Phenylephrine: oral efficacy not well established |