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ACH Pharm

cholinergic pharm

QuestionAnswer
Cholinomimetic agents mimic ACH by binding and activating the receptor (Direct acting)OR Cholinesterase Inhibitors (indirect acting)
Muscarinic transmembrane signaling by G protein linked receptor
Nictoinic transmembrane signaling by Ion channel
Esters of Choline Direct binders ACE, methacoline, carbachol, BETHANECHOL
Absorption of esters of choline poor d/t charge
Alkaloids of ACH Muscarine Pilocarpine Nicotine
Absorption of alkaloids pilocarpine and nictotine absorb well Muscarine not as well absorbed but mushrooms in gut can cause toxicity
Elimination of direct cholinomimetics kidneys....so excretion can be accelerated by decreasing PH of urine
Choinomimetics effects Eye: miosis,accomodation to outflow aqueous humor CV: decrease PVR, decrease HR, EDRF released RESP: contraction of bronchials and increase mucous GI: increase secretory and motor activity in gut, sphincters relaxed
Simple alcohol ACHE Inhibitor edrophonium
Carbomic acid esters of alchol ACHE inhibitor NEOSTIGMINE and PHYSOSTIGMINE covalent bond lasting 30mins to 6 hours
Organic derivatives of phosphoric acid covalent bonding lasting hours and hours Organophosphates (ex isoflurophate) used for pesticides
physostigmine treat glaucoma, atopine intoxication, OD of TCA
neostigmine reverse succ. inrease the tone of esophageal sphincter- decreasing esophagitis Treatment of Myasthenia Gravis
Created by: lndillon
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