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Specialty Pharmacy

Inflammatory Conditions

BrandGenericBasic Info
Cosentxy secukinumab MOA: IL-17 inhibitor Indications: Plaque Psoriasis, Psoriatic Arthritis Administration(general): SubQ, Monthly Unique ADES: IBD exacerbation/new onset
Enbrel etanercept MOA: TNF inhibitor Indications: Plaque Psoriasis, Psoriatic Arthritis,RA,JIA Administration(general): SubQ, weekly Unique ADEs: Cardiac,CNS Biosimilar: Erelzi
Humira adalimumab MOA: TNF inhibitor Indications: Plaque Psoriasis, Psoriatic Arthritis,RA, IBD,JIA,+ Administration(general):SubQ, Q2 Week Unique ADEs: Cardiac,CNS Biosimilars:Amjevita and Cyltezo
Otezla aprimilast MOA: PDE-4 inhibitor Indications: Plaque Psoriasis, Psoriatic Arthritis Administration(general): PO, BID Unique ADEs: GI (severe), Psych Titration pack available
Remicade infliximab MOA: TNF inhibitor Indications: Plaque Psoriasis, Psoriatic Arthritis,RA,IBD,JIA,+ Administration(general): IV, Q2 month Unique ADEs: Cardiovascular, CNS, infusion reaction (premedicate) Biosimilars: Renflexis, Inflectra
Siliq brodalumab MOA: IL-17 inhibitor Indications: Plaque Psoriasis Administration(general): SubQ, Q2 week Unique ADEs: Suicidal Ideation (BBW and REMS), IBD exacerbation/new onset
Stelara ustekinumab MOA: IL-12,23 inhibitor Indications: Plaque Psoriasis, Psoriatic Arthritis,IBD Administration(general):SubQ, Q3 months Unique ADEs: Neurotoxicity (RPLS)
Taltz ixekizumab MOA: IL-17 inhibitor Indications: Plaque Psoriasis Administration(general): SubQ, Monthly Unique ADES: IBD exacerbation/new onset
Tremfya guselkumab MOA: IL-23 inhibitor Indications: Plaque Psoriasis Administration(general): SubQ, Q2 months
Cimzia certolizumab MOA: TNF inhibitor Indications:, Psoriatic Arthritis,RA, IBD,+ Administration(general): SubQ, monthly Unique ADEs: Anemias, CNS, Cardiac
Simponi golimumab MOA: TNF inhibitor Indications:Psoriatic Arthritis,RA, IBD,+ Administration(general):SubQ,monthly Unique ADEs: Anemias, CNS, Cardiac
Actemra tocilzumab MOA: IL-6 inhibitor Indications: RA Administration(general): SUbQ, Weekly
Kineret anakinra MOA: IL-1 inhibitor Indications: RA, + Administration(general): SubQ,daily Unique ADEs: Neuotrophilia(SEVERE) monitor monthly x 3 months, then q3months
Orencia abatacept MOA: T-cell costim-blocker Indications: Psoriatic Arthritis,RA Administration(general):SubQ, weekly Unique ADEs: Worse outcomes in COPD patients
Xeljanx tofactinib MOA: JAK STAT inhibitor Indications: RA,IBD Administration(general):PO, BID (QD for XR) Unique ADES: Bradycard/arrythmia, anemias(dose adjust),liver injury(monitor),lipids (monitor) Renal and Hepatic Dosing- 5mg QD
Entyvio vedolizumab MOA: CAM-1 inhibitor Indications: IBD Administration(general):IV, Q2 months Unique ADES: Liver injury, PML
Inflammatory Conditions Generalizations: Methotrexate OKAY do NOT double up biologics TNF blockers 1st line biologics Vaccinate before initiation: NO LIVE VACCINES during therapy. Avoid in Preg/BF Many also used for Ankylosing spondylitis Warnings for: Infection, Malignancy TB testing, HepB/C, testing SubQ: Refrigerate, don't freeze or shake. Thigh,back of arm, abdomen(rotate)
Created by: Briovastudent
 

 



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