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More NM DOs
NPTE Neuromuscular
| Question | Answer |
|---|---|
| Multiple Sclerosis | chronic, progressive, demyelinating disease of CNS |
| Relapsing Remitting MS | relapses and full or moderate recovery, lack of disease progression between relapses |
| Primary progressive MS | Disease progression from onset without plateau or remission or with occasional temporary improvements |
| Secondary progressive MS | initial relapsing-remitting course followed by progression at variable rate |
| Progressive-relapsing MS | Progressive disease from onset but without clear acute relapses, develop disease after 40yr |
| Sensory problems in MS | hyperpathia, paresthesias, dysesthesias, trigeminal neuralgia, Lhermitte’s sign |
| Hyperpathia | hypersensitivity to sensory stimuli |
| Abnormal sensations | dysesthesias |
| Electric shock like sensation throughout body by flexing neck | Lhermitte’s sign |
| Chronic progressive disease of CNS with degeneration of dopaminergic substantia nigra neurons | Parkinson’s disease |
| Parkinson’s etiology | deficiency of dopamine within the basal ganglia corpus striatum with degeneration of substantia nigra |
| Parkinson’s s/s | rigidity (lead pipe, cogwheel), bradykinesia (hypokinesia), resting tremor, impaired postural reflexes, hypophonia, bradyphrenia, dysphagia, mask like face, small writing, restlessness, pill rolling, festination |
| Abnormal involuntary increase in speed of walking | festination |
| NMJ disorder characterized by progressive muscular weakness & fatigue on exertion | Myasthenia gravis |
| Myasthenia gravis etiology | autoimmune antibody mediated attack on acetylcholine receptors at NMJ |
| Generalized myasthenia | usually bulbar and proximal limb muscles, progressive course |
| Myasthenic crisis | with respiratory failure, medical emergency |
| S/S of myasthenia gravis | diplopia, ptosis, dysarthria, dysphagia, drooping facial muscles, hoarse voice, fatigability, repeated muscle use results in rapid weakness, EMG conclusive |
| Tonic activity | stiffening and rigidity of muscles |
| Clonic activity | rhythmic jerking of extremities |
| Tonic-Clonic Seizure | Grand mal, dramatic LOC |
| Absence seizures | petit mal, brief LOC, no convulsions, may occur very frequently |
| Focal motor seizure | clonic activity involving a specific area of body |
| Focal motor with march (Jacksonian) | orderly spread or march of clonic mvmts |
| Temporal lobe seizures | episodic changes in behavior, hallucinations, automatisms, althered cognitive fxn, emotional fxn, aura |
| Status epilepticus | prolonged or a series of seizures >30min, life threatening |
| Cerebellar lesions tend to produce signs on which side | Ipsilateral |
| Archicerebellum s/s | central vestibular (ocular dysmetria, eye pursuit, VOR, eye-hand coord), gait/trunk ataxia with poor postural control, wide based gait. Little change in tone or dyssynergia of extremities |
| Paleocerebellum s/s | Hypotonia, truncal ataxia (disequilibrium, static postural tremor, sway, wide BOS, high guard), posture worse in Romberg. Ataxic gait with unsteady, falls, decr step length, incr step width |
| Neocerebellum s/s | Ataxic limb mvmts, intention tremors, dysdiadochokinesia, dysmetria, dyssynergia |
| Dyssynergia | abnormal timing, movement decomposition of agonist & antagonist interactions, impairments of complex motor tasks |
| Asthenia | generalized weakness |
| PT goals for Cerebellar Dos | eye-head coord ex, stability ex, approxim, wtd belts, dynamic stab w/ sm range control, smooth reversals of mvmt, graded resist, balance trng, pool-graded resist to decr ataxia & postural instab, low stimulus envi, distributed practice for low endurance |