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Pharmacology

Pharmacodynamics

QuestionAnswer
Pharmacodynamics Study of the interaction between a drug and its molecular target and the pharmacological response
Three main ways drugs can act on receptors Agonist, antagonist, allosteric modulator
Example of an agonist of NACh Acetylcholine, Nicotine
Clinical uses of adrenoceptor beta 1 agonists Adrenalin for cardiac arrest, Dobutamine for cardiogenic shock
Clinical uses of adrenoceptor beta 2 agonist Asthma
Example of drug acting on enzymes NSAIDs e.g. aspirin, ibuprofen; inhibit COX enzymes which are involved in production of mediators involved in pain, fever and inflammation
Drugs acting on transporters SSRIs (selective serotonin reuptake inhibitor) and amphetamines (false substrate for noradrenalin)
Agonist potency The concentration that produces a certain pharmacological response
What two factors determine agonist potency? Efficacy and Affinity
Effector of Kinase-linked receptors Protein kinase
Effector of G-protein coupled receptors Enzyme or ion channel
Effector of nuclear receptors Gene transcription
Coupling of channel-linked receptors Direct
Coupling of G protein coupled receptors G protein
Coupling of kinase-linked receptors Direct or indirect
Coupling of nuclear receptors DNA
Examples of channel-linked receptors nAChr, GABA A, glutamate
Examples of G coupled protein receptors mAChr, adrenoceptors, opiods
Examples of Kinase-linked receptors Insulin receptor, growth factors, cytokine receptors
Examples of Nuclear receptors Steroid hormone receptors
Created by: 813890255
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