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Principles of pharma

Agonist drug Bind to a receptor and trigger the cell's response. Mimic the effect of natural chemical messengers
Antagonist drug Bind to a receptor but does not trigger the cell's response. Block receptors from the effects of their natural chemical messengers. Eg. Atropine
Pharamacology study drugs and and their action on living organisms
Drug Any substance that brings about a change in biological function thru its chemical actions
Receptor A specific PROTEIN in either the plasma membrane or the interior of the target cell ,,,,,,,,,with which a chemical messenger o drug combines
Mechanism of Action The ways by which drugs can produce therapeutic effects
Dose Amount of a drug to be administered at one time
Effect (therapeutic effect) The DESIRED results of administration of a medication
Side effects Effects that are HARMFUL and UNDESIRED, occur in addition to the therapeutic effects.
Indication vs Contra-indication Indications: The reasons for administering a medication or performing a treatment. Contra-indication: Factors that PREVENT the use of a medication or treatment
Onset and duration Onset: The time for the drug to elicit a therapeutic response Duration: For how long of the drug concentration is sufficient to elicit a therapeutic response.
Chemical name vs Generic name vs Brand or trade name
Pharmacokinetics The movements of drug in the body, ADME
Pharmacodynamics What the drug does to the body
Absorption The movement of drug from its point of entry into the circulatory system into the body.
Distribution The manner in which a drug is transported form the site of absorption to the site of action.
Biotransformation The process by which the drug is inactivated and transformed into a form that can be eliminated (mainly liver)
Excretion The process of eliminating drugs out of the body (kidney, liver, intestines,,,)
Half life The time taken for half of the original amount of a drug to be removed.
When will the drug be effectively removed? About 5 half lives
Therapeutic range Drug concentration in the body that produces desired effects in the animal with minimal or no signs of toxicity
Created by: 1934147546612435



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