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Principles of pharma
Term | Definition |
---|---|
Agonist drug | Bind to a receptor and trigger the cell's response. Mimic the effect of natural chemical messengers |
Antagonist drug | Bind to a receptor but does not trigger the cell's response. Block receptors from the effects of their natural chemical messengers. Eg. Atropine |
Pharamacology | study drugs and and their action on living organisms |
Drug | Any substance that brings about a change in biological function thru its chemical actions |
Receptor | A specific PROTEIN in either the plasma membrane or the interior of the target cell ,,,,,,,,,with which a chemical messenger o drug combines |
Mechanism of Action | The ways by which drugs can produce therapeutic effects |
Dose | Amount of a drug to be administered at one time |
Effect (therapeutic effect) | The DESIRED results of administration of a medication |
Side effects | Effects that are HARMFUL and UNDESIRED, occur in addition to the therapeutic effects. |
Indication vs Contra-indication | Indications: The reasons for administering a medication or performing a treatment. Contra-indication: Factors that PREVENT the use of a medication or treatment |
Onset and duration | Onset: The time for the drug to elicit a therapeutic response Duration: For how long of the drug concentration is sufficient to elicit a therapeutic response. |
Chemical name vs Generic name vs Brand or trade name | |
Pharmacokinetics | The movements of drug in the body, ADME |
Pharmacodynamics | What the drug does to the body |
Absorption | The movement of drug from its point of entry into the circulatory system into the body. |
Distribution | The manner in which a drug is transported form the site of absorption to the site of action. |
Biotransformation | The process by which the drug is inactivated and transformed into a form that can be eliminated (mainly liver) |
Excretion | The process of eliminating drugs out of the body (kidney, liver, intestines,,,) |
Half life | The time taken for half of the original amount of a drug to be removed. |
When will the drug be effectively removed? | About 5 half lives |
Therapeutic range | Drug concentration in the body that produces desired effects in the animal with minimal or no signs of toxicity |