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Antimicrobial

Antiinfectives

QuestionAnswer
What are the aerosolized antiinfectives we have learned about? Pentamidine-Nebupent, Ribavirin-Virazole, Tobramycin-TOBI, Zanamivir-Relenza
What is the recommended dosage for Pentamidine/NebuPent? 300mg/6ml sterile water; once/4wks
What is the recommended dosage for Ribavirin/Virazole? 20mg/ml; 12-18hrs/day for 3-7days by SPAG
What is the recommended dosage for Tobramycin?TOBI? 300mg bid; 28 days on/28 days off; >6yrs
What is the recommended dosage for Zanamivir/Relenza? 10mg bid with DPI diskhaler; bid 5 days
What are the indications for Pentamidine/NebuPent? PCP prophylaxis in HIV pt
What are the indications for Ribavirin/Virazole? RSV
What are the indications for Tobramycin/TOBI? P. aeruginosa in CF
What are the indications for Zanamivir/Relenza? Influenza
What is the mode of action for Ribavirin/Virazole? Inhibits DNA replication/reproduction
What special precautions should be taken when delivering Ribavirin/Virazole? PPE's should always be worn; Women who are pregnant or planning pregnancy should not administer
What special precautions should be taken when administering Pentamidine/NebuPent? Use Respigard II neb system, administer in negative pressure room or under exhaust, always wear PPEs
What is the mode of action for Pentamidine/Virazole? Inhibits DNA, RNA, phospholipids and protein synthesis
What is the mode of action for Ribavirin/Virazole? Stops viral DNA replication
What is the mode of action for Tobramycin/TOBI? Bacterialcidal - blocks protein synthesis
What is the mode of action for Zanamivir/Relenza? Binds to viral enzyme and block action
What are the side effects of Tobramycin/TOBI and Gentamicin? Dizziness, nausea, neuromuscular blockade;
What can worsen the side effects of TOBI and Gentamicin? Myasthenia and use of neuromuscular blockades
Created by: kreblackwell