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UGS Pharmacology

Pharmacology of the Urogenital System

Which drug is used for hormone replacement therapy in postmenopausal syndrome? Estrogen
Which drugs can be used for the treatment of osteoporosis? Estrogen and Raloxifene
What are the uses of estrogen therapy? Hormone replacement therapy, osteoporosis, heart attack prevention, oral contraceptives, prostate, breast and endometrial cancer, dysmenorrhea, infertility, acne, hirsutism, and primary hypogonadism
What are the antiestrogens? Tamoxifene and Clomiphine citrate
What are the uses of antiestrogens? Infertility and breast cancer
What is the use of raloxifene? Osteoporosis
What are the aromatase inhibitors? Nonselective aromatase inhibitors: Aminoglutithemide Selective: Anastrazole and Fadrozole
What are the uses of aromatase inhibitors? Breast cancer
What are the uses of progesterone therapy? OCP, dysfunctional uterine bleeding, endometrial, breast, and prostate cancer, abortion, maintaining pregnancy, and endometriosis
What are the anti-progestin drugs? Mefipristone
What are the uses of anti-progestin drugs? Abortifacient, induction of labor, progesterone dependent cancers, and Cushing's syndrome
What are the uses of Gossypol? Male contraception
What are the uses of Ethinylestradiol, DES, and mestranol? Morning-after, emergency pills
Which drugs are used in combined oral contraceptive pills? Ethinylestradiol/Mestranol + Norgestrel Ethinylestradiol/Mestranol + Norethisterone
What are the side effects of estrogen therapy? Postmenopausal uterine bleeding Nausea, vomiting, headache, dizziness, weight gain Salt and water retention Increased BP, thromboembolism, endometrial cancer, and teratogenicity
What are the side effects of progesterone therapy? Depression, weight gain, and salt-water retention
What are the side effects of Mefipristone/Anti-progestin? Delayed ovulation and bleeding
What are the side effects of Gossypol? Interfering with fertility
What are the side effects of OCPs? Nausea, vomiting, dizziness, headaches, nervousness, depression Salt and water retention, increased BP, thromboembolism, MI, Vaginal yeast growth, amennorhea, infertility, atrophy of the hypothalamus
How is Raloxifene administered? Orally
How is medroxyprogesterone/ Progesterone/Provera administered? Intramuscularly or Subdermally
What are the contraindications of OCP use? History of thromboembolism, severe headaches, severe nausea, vomiting, liver dysfunction, pregnancy, and abnormal menstrual cycles
Which drugs can interact with OCPs? Ampicillin, cephalosporins, tetracyclines, sulfonamides, and co-trimaxole
What is the effect on OCPs if they are administered with the drugs they interact with? Their metabolism is decreased
Which drugs when con-administered with OCPs can increase their metabolism? Phenobarbitone, phenytoin, ethosximide, rifampicin, and griseofulvin
What are the uses of PULSATILE GnRH administration? Diagnosis, Deficiency, hypogonadism in males and females, ovulation, delayed puberty, amenorrhea, and crytorchidism
What is a possible cause of GnRH deficiency? Kallman's syndrome
What are the uses of CONTINUOUS GnRH administration? Cancer of the prostate and breast Endometriosis, IVF, precocious puberty, uterine fibroids, uterine leiomyomas, and polycystic ovarian syndrome (PCOS)
What are the GnRH antagonists? Ganirelix
What are the uses of GnRH antagonists? IVF
What are the uses of hCG? Infertility due to LH and FSH deficiency, IVF with menotropin, supress ovulation, and crytorchidism
What are the side effects of GnRH use? Headache, abdominal pain, sweating, facial flushing, hot flashes, and osteoporosis
What are the side effects of hCG use? Allergy, ovarian hyperstimulation syndrome, multiple births, production of specific antibodies, precocious puberty, gynecomastia, and ovarian tumors
What are the clinical manifestations of ovarian hyperstimulation syndrome? Fever, abdominal pain, ovarian enlargement, ascites, pleural effusion, arterial thrombosis, hemoperitoneum, shock, and death
What are the drugs we use in GnRH treatment? Leuprolide acetate, Triptorelin, Goserelin, Histrelin, Nafarelin, and Busereline
How is GnRH administered? SC, IM, IV, Subdermal, intranasal, and Suppository Nafarelin is only administered Intranasal
How is Ganirelix/GnRH antagonist administered? SC
How is hCG administered? IM
Can GnRH be used for contraception? No
Created by: Ulaisl